Evidence map›Paper›PMID 36226150›Full record

ReviewFrontiers in medicine2022

Recent insights in the role of biomarkers in severe asthma management.

Evangelia Fouka, Kalliopi Domvri, Foteini Gkakou, Maria Alevizaki, Paschalis Steiropoulos, Despoina Papakosta, Konstantinos Porpodis

Abstract readReview
In one paragraph

Review in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  13. Roles of Tissue Inhibitor of Metalloproteinase-1 in Severe Asthma.Allergy, asthma & immunology research · 2023
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Evangelia FoukaG. Papanikolaou General Hospital, Thessaloniki, Greece.
Kalliopi DomvriG. Papanikolaou General Hospital, Thessaloniki, Greece.
Foteini GkakouG. Papanikolaou General Hospital, Thessaloniki, Greece.
Maria AlevizakiG. Papanikolaou General Hospital, Thessaloniki, Greece.
Paschalis SteiropoulosDepartment of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Despoina PapakostaG. Papanikolaou General Hospital, Thessaloniki, Greece.
Konstantinos PorpodisG. Papanikolaou General Hospital, Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contemporary asthma management requires a proactive and individualized approach, combining precision diagnosis and personalized treatment. The introduction of biologic therapies for severe asthma to everyday clinical practice, increases the need for specific patient selection, prediction of outcomes and monitoring of these costly and long-lasting therapies. Several biomarkers have been used in asthma in disease identification, prediction of asthma severity and prognosis, and response to treatment. Novel advances in the area of personalized medicine regarding disease phenotyping and endotyping, encompass the development and application of reliable biomarkers, accurately quantified using robust and reproducible methods. The availability of powerful omics technologies, together with integrated and network-based genome data analysis, and microbiota changes quantified in serum, body fluids and exhaled air, will lead to a better classification of distinct phenotypes or endotypes. Herein, in this review we discuss on currently used and novel biomarkers for the diagnosis and treatment of asthma.

Indexed as

biomarkersmicrobiome & dysbiosisnon-T2 airway inflammationomicssevere asthmaT2 asthma

Identifiers

PMID36226150
PMCPMC9548530

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.