ArticleFrontiers in neurology2022
Effect of head-down tilt on clinical outcome and cerebral perfusion in ischemic stroke patients: A case series.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Head Down Position Before Endovascular Treatment for Large Vessel Occlusion: Clinical Trial Design.Journal of the American Heart Association · 2026Trial
- Optimal Head-of-Bed Positioning Before Thrombectomy in Large Vessel Occlusion Stroke: A Randomized Clinical Trial.JAMA neurology · 2025Trial
- Baseline systolic blood pressure and efficacy of dual antiplatelet in acute ischaemic stroke.Stroke and vascular neurology · 2025Trial
- Effects of 12 weeks of Head-Down Strong Abdominal Breathing Training on Gait and Cognitive Function in Patients with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Trial
- A randomized trial of Trendelenburg position for acute moderate ischemic stroke.Nature communications · 2023Trial
- Head-down position after reperfusion improves cerebral ischaemic injury in rat.Stroke and vascular neurology · 2026Article
- Head Positioning for Stroke Blood Flow Augmentation Assisting Reperfusion Therapies Study.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Trendelenburg position for acute anterior circulation ischaemic stroke with large artery atherosclerosis aetiology (HOPES 3): rationale and design.Stroke and vascular neurology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The effect of head position on stroke is not clear. The current study aimed to observe the effect of head-down tilt on acute ischemic stroke (AIS) patients with large vessel occlusion. Methods: We observed the influence of head-down tilt position on clinical outcomes, myocardial enzymogram and N-terminal pro b-type Natriuretic Peptide in 4 AIS patients who suffered early neurological deterioration (END). Cerebral perfusion imaging was performed in 3 patients using arterial spin labeling. Results: In series of AIS patients with END, head down tilt (-20°) prevented further neurological deterioration and improved clinical outcomes. An increase in cerebral blood flow was observed by arterial spin labeling after head down tilt treatment. No obvious adverse events occurred. Conclusion: The case series suggest that head-down tilt may improve clinical outcome in AIS patients through increasing the cerebral perfusion with no obvious adverse events. The finding needs to be confirmed in future clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.