ArticleAlzheimer's & dementia (New York, N. Y.)2022
The role of dyadic cognitive report and subjective cognitive decline in early ADRD clinical research and trials: Current knowledge, gaps, and recommendations.
Article in Alzheimer's & dementia (New York, N. Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Separating ECog scale-score information from dyad availability: observation-process contributions to dyadic prediction of cognitive impairment in ADNI.Research square · 2026Article
- The Cog-Aging: a 15-year cohort study of cognition in Brazilian older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A world view: Considerations of sociocultural diversity in the study of subjective cognitive decline in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The BEYONDD Pilot Study: A Decentralized Community-Engaged Research Framework for Multimodal Characterization of Neurodegenerative Risk in a Multi-Ethnic, Midlife Cohort with Subjective Cognitive or Behavioral Complaints.medRxiv : the preprint server for health sciences · 2026Article
- Evaluating self- and informant-reported complaints as predictors of cognitive progression in subjective cognitive decline: A clinically-based evaluation.Journal of Alzheimer's disease : JAD · 2026Article
- The Role of Dyads in Subjective Reporting and Prediction of Cognitive Worsening in Cognitively Unimpaired Individuals and Individuals with Subjective Cognitive Decline: Results of the CompAS Longitudinal Study.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Sleep phenotypes and subjective cognitive decline in the Hispanic Community Health Study/Study of Latinos.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Increased Worry Associated with Self-Reported, but Not Informant-Reported, Subjective Cognitive Decline Predicts Increased Risk of Incident Dementia.Diagnostics (Basel, Switzerland) · 2025Article
- Clinical definition, biological characterization, and detection guidelines of subjective cognitive decline due to Alzheimer's disease and related dementia: A position paper from ISTAART SCD PIA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Exploring the Feasibility of the LEAD Trial: Online Dyadic Dementia Care Planning for Early Alzheimer's and Other Dementias.The American journal of hospice & palliative care · 2025Article
- Beyond "worried well": health care professionals' perspectives on improving subjective cognitive decline care.The Gerontologist · 2025Article
- Subjective cognitive complaints and future risk of dementia and cognitive impairment, which matters most.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2025Article
- Study partner characteristics moderate the prediction of cognitive decline in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Self- and Informant-Report Cognitive Decline Discordance and Mild Cognitive Impairment Diagnosis.JAMA network open · 2025Observational
- Subjective Cognitive Complaints and Anecdotal Descriptions of Postoperative Cognitive Decline: Missing Pieces of the Postoperative Neurocognitive Disorder Puzzle.Advances in anesthesia · 2024Review
- Predicting brain atrophy and cognitive aging trajectories with baseline subjective cognitive concerns in cognitively normal older adults.Neurobiology of aging · 2024Article
- Understanding what aspects of Parkinson's disease matter most to patients and families.Scientific reports · 2024Article
- Determinants of cognitive dysfunction in adults with sickle cell-related stroke or suspected neurological morbidity.Blood advances · 2024Article
- Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease.iScience · 2024Article
- Brain Health Registry Study Partner Portal: Novel infrastructure for digital, dyadic data collection.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efficient identification of cognitive decline and Alzheimer's disease (AD) risk in early stages of the AD disease continuum is a critical unmet need. Subjective cognitive decline is increasingly recognized as an early symptomatic stage of AD. Dyadic cognitive report, including subjective cognitive complaints (SCC) from a participant and an informant/study partner who knows the participant well, represents an accurate, reliable, and efficient source of data for assessing risk. However, the separate and combined contributions of self- and study partner report, and the dynamic relationship between the two, remains unclear. The Subjective Cognitive Decline Professional Interest Area within the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment convened a working group focused on dyadic patterns of subjective report. Group members identified aspects of dyadic-report information important to the AD research field, gaps in knowledge, and recommendations. By reviewing existing data on this topic, we found evidence that dyadic measures are associated with objective measures of cognition and provide unique information in preclinical and prodromal AD about disease stage and progression and AD biomarker status. External factors including dyad (participant-study partner pair) relationship and sociocultural factors contribute to these associations. We recommend greater dyad report use in research settings to identify AD risk. Priority areas for future research include (1) elucidation of the contributions of demographic and sociocultural factors, dyad type, and dyad relationship to dyad report; (2) exploration of agreement and discordance between self- and study partner report across the AD syndromic and disease continuum; (3) identification of domains (e.g., memory, executive function, neuropsychiatric) that predict AD risk outcomes and differentiate cognitive impairment due to AD from other impairment; (4) development of best practices for study partner engagement; (5) exploration of study partner report as AD clinical trial endpoints; (6) continued development, validation, and optimization, of study partner report instruments tailored to the goals of the research and population.
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