ArticlePlastic and reconstructive surgery. Global open2022
Outcomes of Lymphovenous Anastomosis for Lower Extremity Lymphedema: A Systematic Review.
Article in Plastic and reconstructive surgery. Global open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Efficacy of vascularized lymph node transfer for lower extremity lymphedema: A systematic review and meta-analysis of 395 patients from 25 peer-reviewed studies.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2026Pooled it
- Brain lymphatic drainage pathways, deep cervical lymphatic surgery, and current insights: A systematic review.The journal of prevention of Alzheimer's disease · 2026Pooled it
- The Management of Head and Neck Lymphoedema: A 2025 Systematic Review.Head & neck · 2025Pooled it
- A systematic review of indocyanine green lymphography imaging for the diagnosis of primary lymphoedema.The British journal of radiology · 2025Pooled it
- Artificial Intelligence and Robotic Surgery in Lymphedema: A Scoping Review of Current Applications, Clinical Translation, and Evidence Gaps.Plastic and reconstructive surgery. Global open · 2026Article
- Ultrasound elastography and 3D volumetry for early postoperative assessment after lymphovenous anastomosis in lower-limb lymphedema.Innovative surgical sciences · 2026Article
- Beyond Debulking: Integrating Objective Staging and Physiological Microsurgery in Liposuction for End-Stage Lymphedema.Aesthetic plastic surgery · 2026Article
- Peripheral Lymphatic Shunts for Protein-Losing Enteropathy in a Child with THSD1 Mutation: A Case Report.Archives of plastic surgery · 2026Article
- Can supermicrosurgery treat Alzheimer's disease? - Current evidence and hope.Head & face medicine · 2026Review
- Hemodynamic Challenges of Lower Extremity Lymphovenous Anastomosis: A Critical Reappraisal.Journal of clinical medicine · 2026Review
- Deep cervical lymphovenous reconstruction in Alzheimer's disease: three target-defined interfaces with distinct mechanistic implications.Frontiers in aging neuroscience · 2026Review
- A 5-year prospective assessment of risk factors for lower limb lymphedema after gynecologic cancer surgery.Scientific reports · 2025Article
- Enhancing outcomes in severe lymphedema through combined treatment strategies.World journal of clinical cases · 2025Article
- Prevalence of lower extremity edema following inguinal lymphadenectomy: A systematic review and meta-analysis.JPRAS open · 2025Review
- Advances in surgical management of chronic lymphedema: current strategies and future directions.Medical oncology (Northwood, London, England) · 2025Review
- [Cost comparison of conservative vs. surgical treatment of chronic lymphedema].Chirurgie (Heidelberg, Germany) · 2025Article
- Predicting the Outcome of Lymphovenous Anastomosis for Lower Extremity Lymphedema through Lymphoscintigraphy.International journal of medical sciences · 2025Article
- Lymphovenous Bypass as an Alternative Strategy for Managing Phleboedema and Venous Leg Ulcers: Preliminary Results.Plastic and reconstructive surgery. Global open · 2024Article
- Effects of Lymphaticovenous Anastomosis on Quality of Life, Body Image, and Spiritual Health in Lymphedema Patients: A Prospective Cohort Study.Healthcare (Basel, Switzerland) · 2024Article
- Supermicrosurgical lymphovenous anastomosis.Journal of the Chinese Medical Association : JCMA · 2024Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphovenous anastomosis (LVA) is a microsurgical treatment for lymphedema of the lower extremity (LEL). This study systematically reviews the most recent data on outcomes of various LVA techniques for LEL in diverse patients. Methods: A comprehensive literature search was conducted in the Ovid MEDLINE, Ovid EMBASE, and Scopus databases to extract articles published through June 2021. Studies reporting data on objective postoperative improvement in lymphedema and/or subjective improvement in quality of life for patients with LEL were included. Extracted data comprised demographics, number of patients and lower limbs, duration of symptoms before LVA, surgical technique, duration of follow-up, and objective and subjective outcomes. Results: A total of 303 articles were identified and evaluated, of which 74 were ultimately deemed eligible for inclusion in this study, representing 6260 patients and 2554 lower limbs. The average patient age ranged from 22.6 to 76.14 years. The duration of lymphedema before LVA ranged from 12 months to 11.4 years. Objective rates of improvement in lymphedema ranged from 23.3% to 100%, with the greatest degree of improvement seen in patients with early-stage LEL. Conclusions: LVA is a safe and effective technique for the treatment of LEL of all stages. Several emerging techniques and variations may lead to improved patient outcomes.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.