Evidence map›Paper›PMID 36225707›Full record

ArticleFrontiers in psychology2022

Neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline.

Anita J Fuglestad, Neely C Miller, Birgit A Fink, Christopher J Boys, Judith K Eckerle, Michael K Georgieff, Jeffrey R Wozniak

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Anita J FuglestadDepartment of Psychology, University of North Florida, Jacksonville, FL, United States.
Neely C MillerMasonic Institute for the Developing Brain, University of Minnesota Twin Cities, Minneapolis, MN, United States.
Birgit A FinkDepartment of Psychiatry & Behavioral Sciences, University of Minnesota Twin Cities, Minneapolis, MN, United States.
Christopher J BoysDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, United States.
Judith K EckerleDepartment of Psychiatry & Behavioral Sciences, University of Minnesota Twin Cities, Minneapolis, MN, United States.
Michael K GeorgieffMasonic Institute for the Developing Brain, University of Minnesota Twin Cities, Minneapolis, MN, United States.
Jeffrey R WozniakDepartment of Psychiatry & Behavioral Sciences, University of Minnesota Twin Cities, Minneapolis, MN, United States.
University of Minnesota · USTwin Cities Orthopedics · USUniversity of North Florida · US

Funding

Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum DisordersR01AA024123 · NIAAA · UNIVERSITY OF MINNESOTA · PI GEORGIEFF, MICHAEL K., WOZNIAK, JEFFREY ROBERT · 2015 to 2025
$4.6M
Postnatal Choline Supplementation in Children with Prenatal Alcohol ExposureR33AA019580 · NIAAA · UNIVERSITY OF MINNESOTA · PI WOZNIAK, JEFFREY ROBERT · 2011 to 2013
$647k
Postnatal Choline Supplementation in Children with Prenatal Alcohol ExposureR21AA019580 · NIAAA · UNIVERSITY OF MINNESOTA · PI WOZNIAK, JEFFREY ROBERT · 2009 to 2010
$405k
NIAAA NIH HHS R01 AA024123NIAAA NIH HHS R21 AA019580NIAAA NIH HHS R33 AA019580
6 · The paper itself

Abstract

Background: Prenatal and early postnatal choline supplementation reduces cognitive and behavioral deficits in animal models of Fetal Alcohol Spectrum Disorder (FASD). In a previously published 9-month clinical trial of choline supplementation in children with FASD, we reported that postnatal choline was associated with improved performance on a hippocampal-dependent recognition memory task. The current paper describes the neurophysiological correlates of that memory performance for trial completers. Methods: Children with FASD ( Results: Delayed recall on EI was correlated with two ERP components commonly associated with recognition memory in young children: middle latency negative component (Nc amplitude; range: Conclusion: Although the small sample size limits the ability to draw clear conclusions about the treatment effect of choline on ERP, the results suggest a relationship between memory performance and underlying neurophysiological status in FASD. This trial was registered.

Indexed as

cholineclinical trialevent-related potentialsfetal alcohol spectrum disorders (FAS; FASD)hippocampusmemorytreatment

Identifiers

PMID36225707
PMCPMC9548619
OpenAlexW4297201644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.