Evidence map›Paper›PMID 36225608›Full record

ArticleJournal of ophthalmology2022

Real-Life Efficacy of Bevacizumab Treatment for Macular Edema Secondary to Central Retinal Vein Occlusion according to

Moustafa Hamam, Neil Lagali, Elie Abdulnour, Helen Setterud, Björn Johansson, Pierfrancesco Mirabelli

Open access · goldAbstract read
In one paragraph

Article in Journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Moustafa HamamDepartment of Ophthalmology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping 581 85, Sweden.ORCID https://orcid.org/0000-0002-6707-8852
Neil LagaliDepartment of Ophthalmology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping 581 85, Sweden.ORCID https://orcid.org/0000-0003-1079-4361
Elie AbdulnourDepartment of Ophthalmology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping 581 85, Sweden.ORCID https://orcid.org/0000-0002-0330-1955
Helen SetterudDepartment of Ophthalmology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping 581 85, Sweden.ORCID https://orcid.org/0000-0002-7706-346X
Björn JohanssonDepartment of Ophthalmology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping 581 85, Sweden.ORCID https://orcid.org/0000-0003-4666-3339
Pierfrancesco MirabelliDepartment of Ophthalmology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping 581 85, Sweden.ORCID https://orcid.org/0000-0002-4119-445X
Linköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To present real-life data of patients with macular edema (ME) secondary to central retinal vein occlusion (CRVO) treated with bevacizumab (BVZ); determine the possible influence of epiretinal membrane (ERM) on treatment efficacy; and compare treatment outcomes in a treat-and-extend regimen (TER) versus Methods: We carried out a retrospective analysis of 58 eyes (56 patients) with new-onset CRVO treated only with intravitreal bevacizumab according to TER or PRN. Outcome measures were best-corrected visual acuity (BCVA) and central retinal thickness (CRT) at baseline and 12 months after the first treatment, number of visits and injections, and presence of ERM confirmed by optical coherence tomography in the first 6 months. Results: At 12 months, the mean number of injections was 6.3 across all eyes, with significantly more injections given in TER ( Conclusions: Intravitreal bevacizumab according to either PRN or TER resolved edema and stabilized vision in the first 12 months, with TER yielding significant visual improvement and avoiding neovascular complications. ERM had no influence on bevacizumab efficacy in reducing ME in CRVO during 12 months of treatment.

Identifiers

PMID36225608
PMCPMC9550471
OpenAlexW4300687316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.