Evidence map›Paper›PMID 36225577›Full record

ArticleFrontiers in pharmacology2022

Striatal miR-183-5p inhibits methamphetamine-induced locomotion by regulating glucocorticoid receptor signaling.

Sang-Hoon Song, Won-Jun Jang, Eun Young Jang, Oc-Hee Kim, Haesoo Kim, Taekwon Son, Dong-Young Choi, Sooyeun Lee, Chul-Ho Jeong

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sang-Hoon SongCollege of Pharmacy, Keimyung University, Daegu, South Korea.
Won-Jun JangCollege of Pharmacy, Keimyung University, Daegu, South Korea.
Eun Young JangPharmacology and Drug Abuse Research Group, Korea Institute of Toxicology, Daejeon, South Korea.
Oc-Hee KimPharmacology and Drug Abuse Research Group, Korea Institute of Toxicology, Daejeon, South Korea.
Haesoo KimCollege of Pharmacy, Keimyung University, Daegu, South Korea.
Taekwon SonKorea Brain Bank, Korea Brain Research Institute, Daegu, South Korea.
Dong-Young ChoiCollege of Pharmacy, Yeungnam University, Gyeongsan, South Korea.
Sooyeun LeeCollege of Pharmacy, Keimyung University, Daegu, South Korea.
Chul-Ho JeongCollege of Pharmacy, Keimyung University, Daegu, South Korea.
Keimyung University · KRKorea Institute of Toxicology · KRKorea Brain Research Institute · KRYeungnam University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNA (miRNA)-mediated striatal gene regulation may play an important role in methamphetamine (METH) addiction. This study aimed to identify changes in novel miRNAs and their target genes during METH self-administration and investigate their roles in METH-induced locomotion. RNA sequencing analysis revealed that mir-183-5p was upregulated in the striatum of METH self-administered rats, and target gene prediction revealed that the glucocorticoid receptor (GR) gene,

Indexed as

glucocorticoid receptorlocomotor activitymethamphetaminemicroRNARNA sequencingself-administration

Identifiers

PMID36225577
PMCPMC9549132
OpenAlexW4297227091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.