ArticleCureus2022
Angiomatoid Fibrous Histiocytoma: A Tumor With Uncertain Behavior and Various Clinicopathological Presentations.
Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Intracranial mesenchymal tumor, FET::CREB fusion-positive: An integrative analysis of 81 cases.Neuro-oncology · 2026Article
- Tumor diagnosis recharacterization enabled by comprehensive genomic profiling to guide precision medicine strategy.NPJ precision oncology · 2025Article
- Case Series of Angiomatoid Fibrous Histiocytoma (AFH)-A Clinico-Radiological and Pathological Conundrum.Indian journal of surgical oncology · 2025Article
- Atypical fibrous histiocytoma of the skull: a case report of temporal bone involvement and comprehensive literature review.Frontiers in oncology · 2025Article
- Dermatofibroma: Reappraisal and Updated Review.Clinical, cosmetic and investigational dermatology · 2025Review
- The value of morphology: osteoclast-like cells in soft tissue tumours.Pathology oncology research : POR · 2025Review
- Clinical and pathological analyses of 14 cases of angiomatoid fibrous histiocytoma.Medical molecular morphology · 2024Article
- Angiomatoid Fibrous Histiocytoma Initially Misdiagnosed as Elastofibroma Dorsi: A Case Report and Literature Review.Medicina (Kaunas, Lithuania) · 2024Review
- Difficulties in diagnosing angiomatoid fibrous histiocytoma of the head and neck region: A case report.World journal of clinical cases · 2023Article
- Angiomatoid Fibrous Histiocytoma (AFH) of the Right Arm: An Exceptional Case with Pulmonary Metastasis and Confirmatory EWSR1::CREB1 Translocation.Diagnostics (Basel, Switzerland) · 2022Article
- Definitive Diagnosis of Angiomatoid Fibrous Histiocytoma Using Dual DNA/RNA Genomic Profiling.Cancer diagnosis & prognosisArticle
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue neoplasm of uncertain differentiation, which has various clinical and morphological presentations. Although it behaves in a benign manner, it has malignant potential. Aim To share various histological patterns and survival data in our population of this rare entity. Materials and methods We studied 25 patients who reported AFH from January 2011 to December 2021. Clinical information, gross and histological features, immunohistochemical results, and survival data were compiled and analyzed. Results Among 25 cases reported as AFH, the majority (68%) were males with a mean age of 31.8 years at the time of diagnosis. The most common location was the lower extremity, especially the thigh (56%), and the mean size of the lesion was 55 mm. Most of the lesions were superficial (84%). Grossly, the majority of lesions (76%) had a solid appearance. Microscopically, classic spindle cell morphology was the most common (76%) with a lymphoid cuff and intralesional hemorrhage. Mild cellular atypia was seen in most (92%) of the cases, while some biopsies (8%) had a high-grade morphology. The majority of patients were alive, while one patient died of the disease. Conclusion AFH is an under-recognized entity with various clinical and histological presentations and a low malignant potential.
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