ArticleCureus2022
Seizure as the Main Manifestation of Nonalcoholic Wernicke's Encephalopathy but Without Cortical Involvement: A Case Report.
Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wernicke's encephalopathy (WE) is an underdiagnosed entity. A seizure can be the main manifestation of WE even without cortical involvement. This is a case report of a 45-year-old female patient with a past medical history of depression and poor oral intake who presented with a single episode of unwitnessed seizure and three days of unsteady gait and vertigo. She then had two episodes of seizure, focal and then generalized tonic. Her physical examination was remarkable for lethargy and bilateral gaze-induced horizontal nystagmus with a rotational component and change in direction. Magnetic resonance imaging (MRI) of the brain with contrast showed non-enhancing bilateral symmetrical fluid-attenuated inversion recovery (FLAIR) hyperintensities in the medial thalami and tectum. Vitamin B1 level was found to be low. Lumbar puncture (LP) was unyielding. She was loaded with high-dose thiamine replacement. After a few days, a neurological examination revealed improvement with unilateral nystagmus with less lethargy. The valproate that was started initially was eventually discontinued during follow-up after the resolution of neurological deficits. Interestingly, baseline echocardiography showed heart failure with reduced ejection fraction at 40% with clinical euvolemia. It was believed to be secondary to beriberi.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.