Evidence map›Paper›PMID 36225259›Full record

ArticleFrontiers in molecular biosciences2022

Moving HER2-low breast cancer predictive and prognostic data from clinical trials into the real world.

Serena Di Cosimo, Eliana La Rocca, Silva Ljevar, Maria Carmen De Santis, Marta Bini, Vera Cappelletti, Marta Valenti, Paolo Baili, Filippo G de Braud, Secondo Folli and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Comparison of clinical characteristics and survival between HER2-zero and HER2-low in early breast cancer: a retrospective observational study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Observational
  6. Article
  7. Article
  8. Article
  9. HER2-Low Breast Cancer: Now and in the Future.Cancer research and treatment · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Serena Di CosimoIntegrated Biology Platform Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Eliana La RoccaRadiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Silva LjevarClinical Epidemiology and Trial Organization Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Maria Carmen De SantisRadiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Marta BiniRadiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Vera CappellettiBiomarkers Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Marta ValentiBiomarkers Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Paolo BailiAnalytic Epidemiology and Health Impact Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Filippo G de BraudBreast Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Secondo FolliBreast Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Gianfranco ScaperrottaBreast Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Chiara VolpiBreast Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Andrea VingianiBreast Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Claudio VernieriBreast Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Paolo VerderioBioinformatics and Biostatistics Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy.
Rosalba MiceliClinical Epidemiology and Trial Organization Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Giancarlo PruneriBreast Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Fondazione IRCCS Istituto Nazionale dei Tumori · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

breast cancerHER2-lowneoadjuvant chemotherapypredictiveprognostic

Identifiers

PMID36225259
PMCPMC9549400
OpenAlexW4297237943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.