Evidence map›Paper›PMID 36225195›Full record

ArticleDisease markers2022

Senkyunolide H Affects Cerebral Ischemic Injury through Regulation on Autophagy of Neuronal Cells via P13K/AKT/mTOR Signaling Pathway.

Bei Zhao, Ke-Cheng Tang, Ying Zhao, Wang Zhao

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Bei ZhaoDepartment of Neurology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010030 Inner Mongolia, China.
Ke-Cheng TangDepartment of General Surgery, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010030 Inner Mongolia, China.
Ying ZhaoDepartment of Laboratory, Shanghai Xuhui District Dahua Hospital, Shanghai 200231, China.
Wang ZhaoDepartment of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing Key Laboratory of Cerebrovascular Disease Research, Chongqing 402160, China.ORCID https://orcid.org/0000-0003-4110-7544
Chongqing Medical University · CNDahua Hospital · CNInner Mongolia Medical University · CNSecond Affiliated Hospital of Inner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral ischemia (CI) is associated with high global incidence and risk; therefore, its rapid and reliable therapeutic management is essential for protecting patients' lives and improving health. Senkyunolide H (SH) is remarkably effective against phlebosclerosis, oxidation, and apoptosis. Blood-brain barrier is the main obstacle impeding the delivery of drugs and xenobiotics to brain areas. Drugs' loading in nanoparticles can overcome the blood-brain barrier obstacle and thus directly and completely act on brain tissue, and such a loading can also change the half-life of drugs

Indexed as

Brain InjuriesBrain IschemiaAnimalsApoptosisAutophagyBenzofuransLiposomesNanoparticlesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsSignal TransductionTOR Serine-Threonine KinasesWaterXenobioticsBenzofuransLipid NanoparticlesLiposomesmTOR protein, ratPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktsenkyunolide HTOR Serine-Threonine KinasesWaterXenobiotics

Identifiers

PMID36225195
PMCPMC9550497
OpenAlexW4300817300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.