Evidence map›Paper›PMID 36225172›Full record

ArticleOxidative medicine and cellular longevity2022

Pathogenesis and Diagnostic Significance of EBV-miR-BARTs in Nasopharyngeal Carcinoma.

Zhen Wu, Xiaoling Zhang, Pinjing Liu, Aiyou Wei, Wei Ouyang, Shengjun Xiao

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Zhen WuXiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Xiaoling ZhangDepartment of Physiology, Faculty of Basic Medical Science, Guilin Medical University, Guilin, Guangxi 541100, China.
Pinjing LiuDepartment of Hematology, Guigang People's Hospital, Guigang, Guangxi 537100, China.
Aiyou WeiDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510000, China.
Wei OuyangCollege of Nursing, Guilin Medical University, Guilin, Guangxi 541100, China.
Shengjun XiaoDepartment of Pathology, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541100, China.ORCID https://orcid.org/0000-0003-0582-5944
Guilin Medical University · CNCentral South University · CNGuigang City People's Hospital · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Examining the role of EBV-miR-BARTs in nasopharyngeal cancer etiology and diagnosis. Method: As the subjects of this study, nasopharyngeal cancer cell lines were chosen and then randomly assigned to one of four groups: the control group, EBV-miR-BART5-3p NC, EBV-miR-BART5-3p mimics, and EBV-miR-BART5-3p inhibitor groups. Utilizing reverse transcription polymerase chain reaction, we determined the levels of gene expression in nasopharyngeal cancer cells that had been treated with EBV-miR-BART5-3p (RT-PCR). The MTT, Transwell, and scratch tests were used to determine the degree to which cells underwent apoptosis, invasion, and migration. The Western blotting method was used in order to examine the protein expression. Result: Compared with normal nasopharyngeal cells, Conclusion: The understanding that inhibiting expression of EBV-miR-BART5-3p might reduce the risk of developing nasopharyngeal cancer may help direct clinical treatment for the condition.

Indexed as

MicroRNAsNasopharyngeal NeoplasmsApoptosisbcl-2-Associated X ProteinCaspase 3Cell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHerpesvirus 4, HumanHumansMatrix Metalloproteinase 2Matrix Metalloproteinase 9Nasopharyngeal Carcinomabcl-2-Associated X ProteinCaspase 3Matrix Metalloproteinase 2Matrix Metalloproteinase 9MicroRNAs

Identifiers

PMID36225172
PMCPMC9550407
OpenAlexW4300594307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.