ArticleAnimal models and experimental medicine2022
Different coding characteristics between flight and freezing in dorsal periaqueductal gray of mice during exposure to innate threats.
Article in Animal models and experimental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 13 citations in OpenAlex.
- Tail-rattling in rodents: more than a threat display.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- A novel role for the infralimbic cortex in conditioned fear responding.Oxford open neuroscience · 2026Article
- Behavioral and neural correlates of diverse conditioned fear responses in male and female rats.Neurobiology of stress · 2024Article
- Repeated presentation of visual threats drives innate fear habituation and is modulated by environmental and physiological factors.bioRxiv : the preprint server for biology · 2024Article
- Behavioral and neural correlates of diverse conditioned fear responses in male and female rats.bioRxiv : the preprint server for biology · 2024Article
- A novel small-animal locomotor activity recording device for biological clock research.Animal models and experimental medicine · 2024Article
- On Including Pain as an Integral Part of the Fight-or-Flight Response.Journal of pain research · 2024Article
- The contribution of periaqueductal gray in the regulation of physiological and pathological behaviors.Frontiers in neuroscience · 2024Review
- Beyond Fear, Extinction, and Freezing: Strategies for Improving the Translational Value of Animal Conditioning Research.Current topics in behavioral neurosciences · 2023Article
- Different coding characteristics between flight and freezing in dorsal periaqueductal gray of mice during exposure to innate threats.Animal models and experimental medicine · 2022Article
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6 authors at 2 institutions in 1 country.
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Abstract
backgroundFlight and freezing are two vital defensive behaviors that mice display to avoid natural enemies. When they are exposed to innate threats, visual cues are processed and transmitted by the visual system into the emotional nuclei and finally transmitted to the periaqueductal gray (PAG) to induce defensive behaviors. However, how the dorsal PAG (dPAG) encodes the two defensive behaviors is unclear.
methodsMulti-array electrodes were implanted in the dPAG nuclei of C57BL/6 mice. Two kinds of visual stimuli (looming and sweeping) were used to induce defensive behaviors in mice. Neural signals under different defense behaviors were recorded, and the encoding characteristics of the two behaviors were extracted and analyzed from spike firing and frequency oscillations. Finally, synchronization of neural activity during the defense process was analyzed.
resultsThe neural activity between flight and freezing behaviors showed different firing patterns, and the differences in the inter-spike interval distribution were mainly reflected in the 2-10 ms period. The frequency band activities under both defensive behaviors were concentrated in the theta band; the active frequency of flight was ~8 to 10 Hz, whereas that of freezing behavior was ~6 to 8 Hz. The network connection density under both defense behaviors was significantly higher than the period before and after defensive behavior occurred, indicating that there was a high synchronization of neural activity during the defense process.
conclusionsThe dPAG nuclei of mice have different coding features between flight and freezing behaviors; during strong looming stimulation, fast neuro-instinctive decision making is required while encountering weak sweeping stimulation, and computable planning late behavior is predicted in the early stage. The frequency band activities under both defensive behaviors were concentrated in the theta band. There was a high synchronization of neural activity during the defense process, which may be a key factor triggering different defensive behaviors.
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