Evidence map›Paper›PMID 36224758›Full record

ReviewBiotechnology and bioengineering2023

Genome editing technologies, mechanisms and improved production of therapeutic phytochemicals: Opportunities and prospects.

Sicon Mitra, Uttpal Anand, Mimosa Ghorai, Nishi Kant, Manoj Kumar, Radha, Niraj K Jha, Mallappa K Swamy, Jarosław Proćków, José M Pérez de la Lastra and 1 more

Abstract readReview
In one paragraph

Review in Biotechnology and bioengineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sicon MitraDepartment of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh, India.
Uttpal AnandBen-Gurion University of the Negev, Israel.ORCID 0000-0001-5924-7866
Mimosa GhoraiDepartment of Life Sciences, Presidency University, Kolkata, West Bengal, India.
Nishi KantDepartment of Chemical Engineering, Indian Institute of Technology Delhi, Delhi, New Delhi, India.
Manoj KumarChemical and Biochemical Processing Division, ICAR-Central Institute for Research on Cotton Technology, Mumbai, Maharashtra, India.
RadhaSchool of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, India.
Niraj K JhaDepartment of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh, India.
Mallappa K SwamyDepartment of Biotechnology, East West First Grade College of Science, Bengaluru, Karnataka, India.
Jarosław ProćkówDepartment of Plant Biology, Institute of Environmental Biology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.
José M Pérez de la LastraBiotechnology of Macromolecules Research Group, Department of Life and Earth Sciences, Instituto de Productos Naturales y Agrobiología-Consejo Superior de Investigaciones Científicas, (IPNA-CSIC), San Cristóbal de La Laguna, Tenerife, Spain.
Abhijit DeyDepartment of Life Sciences, Presidency University, Kolkata, West Bengal, India.

Funding

Agencia Canaria de Investigación, Innova-ción y Sociedad de la Información (ACIISI) del Gobierno de Canarias ProID2020010134APOGEO (Cooperation Program INTERREG-MAC 2014-2020, with European Funds for Regional Development-FEDER)Fundación CajaCanarias 2019SP43
6 · The paper itself

Abstract

Plants produce a large number of secondary metabolites, known as phytometabolites that may be employed as medicines, dyes, poisons, and insecticides in the field of medicine, agriculture, and industrial use, respectively. The rise of genome management approaches has promised a factual revolution in genetic engineering. Targeted genome editing in living entities permits the understanding of the biological systems very clearly, and also sanctions to address a wide-ranging objective in the direction of improving features of plant and their yields. The last few years have introduced a number of unique genome editing systems, including transcription activator-like effector nucleases, zinc finger nucleases, and miRNA-regulated clustered regularly interspaced short palindromic repeats/Cas9 (CRISPR/Cas9). Genome editing systems have helped in the transformation of metabolic engineering, allowing researchers to modify biosynthetic pathways of different secondary metabolites. Given the growing relevance of editing genomes in plant research, the exciting novel methods are briefly reviewed in this chapter. Also, this chapter highlights recent discoveries on the CRISPR-based modification of natural products in different medicinal plants.

Indexed as

CRISPR-Cas SystemsGene EditingMetabolic EngineeringPhytochemicalsPlantsPhytochemicalsbiosynthesis pathwayCRISPR/Casgene encodinghomozygous mutantsknockoutnext-generation sequencing

Identifiers

PMID36224758
PMCPMC10091730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.