Evidence map›Paper›PMID 36224585›Full record

SynthesisMalaria journal2022

The choice of reference chart affects the strength of the association between malaria in pregnancy and small for gestational age: an individual participant data meta-analysis comparing the Intergrowth-21 with a Tanzanian birthweight chart.

George Mtove, Daniel T R Minja, Omari Abdul, Samwel Gesase, Kenneth Maleta, Titus H Divala, Noel Patson, Ulla Ashorn, Miriam K Laufer, Mwayiwawo Madanitsa and 11 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Malaria journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Fetal growth and birth weight are independently reduced by malaria infection and curable sexually transmitted and reproductive tract infections in Kenya, Tanzania, and Malawi: A pregnancy cohort study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 6 countries.

George MtoveTanga Medical Research Centre, National Institute for Medical Research, P. O. Box, 210, Tanga, Tanzania. mtoveg2002@gmail.com.
Daniel T R MinjaTanga Medical Research Centre, National Institute for Medical Research, P. O. Box, 210, Tanga, Tanzania.
Omari AbdulTanga Medical Research Centre, National Institute for Medical Research, P. O. Box, 210, Tanga, Tanzania.
Samwel GesaseTanga Medical Research Centre, National Institute for Medical Research, P. O. Box, 210, Tanga, Tanzania.
Kenneth MaletaKamuzu University of Health Sciences, Blantyre, Malawi.
Titus H DivalaKamuzu University of Health Sciences, Blantyre, Malawi.
Noel PatsonKamuzu University of Health Sciences, Blantyre, Malawi.
Ulla AshornTampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Miriam K LauferUniversity of Maryland School of Medicine, Baltimore, USA.
Mwayiwawo MadanitsaMalawi University of Science and Technology, Thyolo, Malawi.
Per AshornFaculty of Medicine and Health Technology, Center for Child, Adolescent, and Maternal Health Research, Tampere University, Tampere, Finland.
Don MathangaKamuzu University of Health Sciences, Blantyre, Malawi.
Jobiba ChinkhumbaKamuzu University of Health Sciences, Blantyre, Malawi.
Julie R GutmanMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, US Centers for Diseases Control and Prevention, Atlanta, GA, USA.
Feiko O Ter KuileDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Sofie Lykke MøllerSection of Global Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Ib C BygbjergSection of Global Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Michael AlifrangisCentre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Thor TheanderCentre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
John P A LusinguTanga Medical Research Centre, National Institute for Medical Research, P. O. Box, 210, Tanga, Tanzania.
Christentze SchmiegelowCentre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
National Institute for Medical Research · TZKamuzu Central Hospital · MWUniversity of Copenhagen · DKCopenhagen University Hospital · DKCenter for Global Health · USKamuzu University of Health SciencesLiverpool School of Tropical Medicine · GBMalawi University of Science and Technology · MWTampere University · FITampere University · FIUniversity of Maryland, Baltimore · US

Funding

European and Developing Countries Clinical Trials Partnership Grant no TRIA-2015-1076-IMPROVEMedical Research Council MC_PC_MR/P006914/1Wellcome Trust
6 · The paper itself

Abstract

backgroundThe prevalence of small for gestational age (SGA) may vary depending on the chosen weight-for-gestational-age reference chart. An individual participant data meta-analysis was conducted to assess the implications of using a local reference (STOPPAM) instead of a universal reference (Intergrowth-21) on the association between malaria in pregnancy and SGA.

methodsIndividual participant data of 6,236 newborns were pooled from seven conveniently identified studies conducted in Tanzania and Malawi from 2003-2018 with data on malaria in pregnancy, birthweight, and ultrasound estimated gestational age. Mixed-effects regression models were used to compare the association between malaria in pregnancy and SGA when using the STOPPAM and the Intergrowth-21 references, respectively.

resultsThe 10th percentile for birthweights-for-gestational age was lower for STOPPAM than for Intergrowth-21, leading to a prevalence of SGA

conclusionsThe prevalence of SGA may be overestimated and the impact of malaria in pregnancy underestimated when using Intergrowth-21. Comparing local reference charts to global references when assessing and interpreting the impact of malaria in pregnancy may be appropriate.

Indexed as

Infant, Small for Gestational AgeMalariaBirth WeightFemaleFetal Growth RetardationGestational AgeHumansInfant, NewbornPregnancyTanzaniaBirthweightIndividual participant data meta-analysisMalaria in pregnancyReference chart

Identifiers

PMID36224585
PMCPMC9559842
OpenAlexW4304692434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.