ReviewNature reviews. Endocrinology2023
The multiple roles of life stress in metabolic disorders.
Review in Nature reviews. Endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
178 citing papers in PubMed, 3 syntheses or guidelines pooled it, 237 citations in OpenAlex.
- The Fundamental Frequency of Voice as a Potential Stress Biomarker: A Systematic Review and Meta-Analysis.Stress and health : journal of the International Society for the Investigation of Stress · 2025Pooled it
- Sociodemographic and work-related determinants of self-rated health trajectories: a collaborative meta-analysis of cohort studies from Europe and the US.Scientific reports · 2025Pooled it
- Pooled it
- Examining the Impact of Acute Exercise and Arousal Reappraisal on Stressor-Evoked Psychological and Cardiovascular Responses.Psychophysiology · 2026Trial
- Association between stress-related exposures and risk of pre-diabetes and type 2 diabetes: results from the population-based Lifelines cohort study.BMJ open diabetes research & care · 2026Article
- The "Selfish Cell": The Central Role of Metabolism in Relaying Environmental Stimuli and Controlling Cellular Function.Biology · 2026Review
- A targeted metabolic intervention via exercise applied after vaccination shapes kinetics and durability of serum antibody accompanied by a distinct immunometabolic signature: pilot study.Brain, behavior, & immunity - health · 2026Article
- Association of psychosocial stress with altered functional connectivity of large-scale brain networks in aging adults.Cognitive, affective & behavioral neuroscience · 2026Article
- Advances in salivary cortisol monitoring for healthcare applications.RSC advances · 2026Review
- Stressful exposure from the 2004 Indian Ocean Tsunami drives long-term changes in thyroid hormone physiology.bioRxiv : the preprint server for biology · 2026Article
- Income Volatility and Risk of All-Cause Mortality and Cause-Specific Hospitalization Among Adults With Depression: A Nationwide Cohort Study.Journal of Korean medical science · 2026Article
- Work stress and healthy aging: A conceptual framework for the Semmelweis study and the Semmelweis-EUniWell workplace health promotion model program.GeroScience · 2026Review
- Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026Review
- Altered Neurovascular Coupling Dynamics During Dobutamine-Induced Acute Stress.Brain and behavior · 2026Article
- An Ultrathin, Permeable, and Battery-Free Monolithically Integrated System for Emotion Sensing and Interaction.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Article
- Review
- Stress recovery effects of visual exposure to bamboo landscapes in urban parks: Evidence from physiological and psychological responses.Scientific reports · 2026Article
- Determinants of the plasma metabolome: cross-sectional and longitudinal associations over six years in the NESDA cohort.EBioMedicine · 2026Article
- Early-life adversity before age 5 is associated with reduced cardiometabolic health characterized by increased arterial stiffness and inflammation in adolescence.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
118 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 4 countries.
Funding
Abstract
The activation of stress-related neuroendocrine systems helps to maintain homeostasis, but excessive stress can damage body functions. We review current evidence from basic sciences and epidemiology linking stress to the development and progression of metabolic disorders throughout life. Findings from rodents demonstrate that stress can affect features of metabolic dysfunction, such as insulin resistance, glucose and lipid homeostasis, as well as ageing processes such as cellular senescence and telomere length shortening. In human studies, stressors in the home, workplace and neighbourhood are associated with accelerated ageing and metabolic and immune alterations, both directly and indirectly via behavioural risks. The likelihood of developing clinical conditions, such as diabetes mellitus and hepatic steatosis is increased in individuals with adverse childhood experiences or long-term (years) or severe stress at work or in private life. The increased risk of metabolic disorders is often associated with other stress-related conditions, such as mental health disorders, cardiovascular disease and increased susceptibility to infections. Equally, stress can worsen prognosis in metabolic diseases. As favourable modifications in stressors are associated with reductions in incidence of metabolic disorders, further investigation of the therapeutic value of targeting stress in personalized medicine is warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.