ArticleEnvironmental health perspectives1987
Two-hour methyl isocyanate inhalation exposure and 91-day recovery: a preliminary description of pathologic changes in F344 rats.
Article in Environmental health perspectives, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Bhopal, Dunsmuir and TRPA1: what they have taught us about nociception.Frontiers in allergy · 2025Review
- Alleviation of methyl isocyanate-induced airway obstruction and mortality by tissue plasminogen activator.Annals of the New York Academy of Sciences · 2020Article
- Persistent effects of chlorine inhalation on respiratory health.Annals of the New York Academy of Sciences · 2016Review
- Olfactory toxicity of methyl iodide in the rat.Archives of toxicology · 1995Article
- Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction.Drug safety · 1994Review
- Sequential respiratory, psychologic, and immunologic studies in relation to methyl isocyanate exposure over two years with model development.Environmental health perspectives · 1992Article
- Functional evidence of persistent airway obstruction in rats following a two-hour inhalation exposure to methyl isocyanate.Environmental health perspectives · 1987Article
- Ultrastructural changes in the nasal mucosa of Fischer 344 rats and B6C3F1 mice following an acute exposure to methyl isocyanate.Environmental health perspectives · 1987Article
- Toxicity of inhaled methyl isocyanate in F344/N rats and B6C3F1 mice. I. Acute exposure and recovery studies.Environmental health perspectives · 1987Article
- The toxicity of inhaled methyl isocyanate in F344/N rats and B6C3F1 mice. II. Repeated exposure and recovery studies.Environmental health perspectives · 1987Article
- Effect of methyl isocyanate (MIC) gas on the eyes of Fischer 344 rats.Environmental health perspectives · 1987Article
- Cardiopulmonary effects in awake rats four and six months after exposure to methyl isocyanate.Environmental health perspectives · 1987Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The accidental release of methyl isocyanate (MIC) in Bhopal, India, was reportedly responsible for the deaths of more than 2,000 people. To study the pathology of acute inhalation exposure to MIC, the tissues of male and female Fischer 344 rats were evaluated immediately after a single 2-hr exposure to 0, 3, 10, or 30 ppm MIC, and through day 91. Early gross pathologic changes in the 30 ppm-exposed rats included a reddish white encrustation around the mouth and nose, a small thymus, and distension of the gastrointestinal tract with gas. Lungs (middle and median lobes) showed consolidation and hemorrhage and failed to deflate when the chest cavity was opened. Microscopic changes in the upper respiratory tract 3 hr after exposure included marked erosion and separation of olfactory and respiratory epithelia from the basement membrane with accumulation of serofibrinous fluid. On day 1, acute inflammation and fibrinopurulent exudate partially blocked the nasal passages. Epithelial cells had sloughed from the nasopharynx, trachea, bronchi, and major bronchioles, leaving the basement membrane covered with fibrin and exudate. Granulomatous inflammation and intraluminal fibrosis of the airways were observed by day 3, with increased intraluminal fibrosis by day 7. Lower airways became blocked by exfoliated cells, mucous plugs, and/or intraluminal fibrosis.(ABSTRACT TRUNCATED AT 250 WORDS)
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