Evidence map›Paper›PMID 36224441›Full record

ArticleMedical oncology (Northwood, London, England)2022

Investigation of molecular mechanisms underlying JAK/STAT signaling pathway in HPV-induced cervical carcinogenesis using 'omics' approach.

Kulbhushan Thakur, Divya Janjua, Gauri Shishodia, Arun Chhokar, Nikita Aggarwal, Joni Yadav, Tanya Tripathi, Apoorva Chaudhary, Anna Senrung, Alok Chandra Bharti

Abstract read
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In one paragraph

Article in Medical oncology (Northwood, London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Kulbhushan ThakurMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), New Delhi, 110007, India.
Divya JanjuaMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), New Delhi, 110007, India.
Gauri ShishodiaDivision of Molecular Oncology, Institute of Cytology and Preventive Oncology, Noida, India.
Arun ChhokarMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), New Delhi, 110007, India.
Nikita AggarwalMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), New Delhi, 110007, India.
Joni YadavMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), New Delhi, 110007, India.
Tanya TripathiMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), New Delhi, 110007, India.
Apoorva ChaudharyMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), New Delhi, 110007, India.
Anna SenrungMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), New Delhi, 110007, India.
Alok Chandra BhartiMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), New Delhi, 110007, India. alokchandrab@yahoo.com.ORCID http://orcid.org/0000-0002-5996-2832
University of Delhi · INSouthwestern Medical Center · US

Funding

CCRH 17-51/2016-17/CCRH/Tech/Coll./DU-CervicalCancer.4850CSIR 09/0045/(11635)/2021-EMR-ICSIR 09/0045/(12901)/2022-EMR-ICSIR 09/045(1622)/2019-EMR-ICSIR 09/045(1629)/2019-EMR-ICSIR-UGC 573(CSIR-UGC NET JUNE 2017)CSIR-UGC 764/(CSIR-UGC NET JUNE 2019)DST-SERB EMR/2017/004018/BBMIndian Council of Medical Research 5/13/38/2014-NCD-IIIIndian Council of Medical Research 5/13/4/ACB/ICRC/2020/NCD-IIIIOE, University of Delhi IOE/2021/12/FRP_dated31.08.2022
6 · The paper itself

Abstract

The precise mechanism of action of Janus Kinases (JAK)/Signal Transducer and activator of Transcription (STAT) signaling in human papillomavirus (HPV)-associated cervical cancer (CaCx) is poorly defined. The present study dissected the underlying components of JAK/STAT signaling in HPV-positive cervical neoplasms. Whole transcriptome profile of CaCx cohort from TCGA database revealed elevated STAT3 and its impact on CaCx patients' survival. Using the RT

Indexed as

AlphapapillomavirusPapillomavirus InfectionsUterine Cervical NeoplasmsCarcinogenesisErbB ReceptorsFemaleHumansInterleukin-4Janus KinasesPapillomaviridaeRNA, MessengerSignal TransductionErbB ReceptorsInterleukin-4Janus KinasesRNA, MessengerCervical cancer (CaCx)Differentially expressed genes (DEGs)Human papillomavirus (HPV)Janus Kinases (JAK)/Signal Transducer and activator of Transcription (STAT) pathway

Identifiers

PMID36224441
OpenAlexW4304808057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.