ArticleNature2022
Activation of γ-globin expression by hypoxia-inducible factor 1α.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
What it found
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Who cites it
44 citing papers in PubMed, 60 citations in OpenAlex.
- A multilevel mHealth intervention boosts adherence to hydroxyurea in individuals with sickle cell disease.Blood advances · 2023Trial
- Positive feedback loop via HIF-1α lactylation driven by kynurenine promotes glycolysis.Oncogene · 2026Article
- Proteasome-Enriched hPPSCs-Derived EVs Attenuate Hypoxic Injury in Endothelial Cells via Proteasome-Mediated HIF-1α Degradation.International journal of molecular sciences · 2026Article
- New Gene Therapy Strategy for β-Thalassemia.Stem cell reviews and reports · 2026Review
- Daprodustat augments red cell and γ-globin production in models of sickle cell disease.Blood red cells & iron · 2026Article
- CDK6/4 inactivates BAP1 deubiquitinase destabilizing VHL to promote metastatic colonization in liver.Molecular cancer · 2026Article
- Article
- FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.Cell reports. Medicine · 2026Article
- Roxadustat induced fetal hemoglobin in anemic CKD patients: a dual-center real-world observational cohort study.BMC nephrology · 2026Observational
- p27Kip1 regulates γ-globin production.Blood · 2026Article
- Highly discriminative globin gene activation by the noncanonical BAF chromatin remodeling complex.Blood · 2026Article
- Enhanced induction of fetal hemoglobin by the combination of decitabine with RN-1 in β-thalassemia/HbE erythroid progenitor cells.Molecular medicine (Cambridge, Mass.) · 2026Article
- Changes in Fetal Hemoglobin in Very Preterm Infants Born Small for Gestational Age: A Retrospective Observational Study.Children (Basel, Switzerland) · 2026Article
- MAZ regulates fetal hemoglobin repression by activating MYB transcription.Scientific reports · 2025Article
- Stage-specific TRIM10 expression regulates erythroid maturation.EMBO reports · 2025Article
- Selective AMPKβ1 activation induces fetal hemoglobin in human erythroid cells and sickle cell mice via the noncanonical NRF2 pathway.Science advances · 2025Article
- Mechanisms of Globin Gene Regulation in Mammals.Annual review of genetics · 2025Review
- Comprehensive regulation of γ-globin expression by epigenetic modifications and protein post-translational modifications.Clinical epigenetics · 2025Review
- Variation in metabolic pattern regulation under hypoxic conditions: a comparative study of rodents distributed at different altitudes.Frontiers in zoology · 2025Article
- Exploring the Role of LINC00115 in Esophageal Squamous Cell Carcinoma: Insights Into JAK1/STAT3 Pathway Activation and Metastatic Potential.JCO precision oncology · 2025Article
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Authors and funding
16 authors at 3 institutions in 1 country.
Ruopeng FengDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA.
Thiyagaraj MayuranathanDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA.
Peng HuangDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3008-851X
Phillip A DoerflerDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-7566-9073
Yichao LiDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-5791-096X
Yu YaoDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA.
Jingjing ZhangDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA.
Lance E PalmerDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-2519-8602
Kalin MayberryDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA.
Georgios E ChristakopoulosDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA.
Peng XuDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA.
Chunliang LiDepartment of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-5938-5510
Yong ChengDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-9314-0971
Gerd A BlobelDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0714-9612
M Celeste SimonAbramson Family Cancer Research Institute, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-9106-447X
Mitchell J WeissDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN, USA. mitch.weiss@stjude.org.ORCID http://orcid.org/0000-0003-2460-3036
St. Jude Children's Research Hospital · USChildren's Hospital of Philadelphia · USCancer Research Institute · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MVIROSOME/PROTEOLIPOSOME MEDIATED GENE TRANSFERP01HL053749 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEISS, MITCHELL J · 1994 to 2022
$43.6MMetabolic Tumor Suppressors in Renal Cancer: Unprecedented Roles in Disease ProgressionR35CA220483 · NCI · UNIVERSITY OF PENNSYLVANIA · PI M. CELESTE SIMON · 2017 to 2026
$9.4MRegulation of Hemoglobin SwitchingR01HL119479 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Gerd A Blobel · 2013 to 2026
$8.0MVISION: ValIdated Systematic IntegratiON of epigenomic dataR24DK106766 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI BLOBEL, GERD A, BODINE, DAVID M. · 2016 to 2020
$6.2MPedGeneRx - Admin Supplement to Base Editing and Prime Editing for Sickle Cell Disease R01R01HL156647 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Agnieszka Czechowicz, DAVID R LIU · 2021 to 2026
$4.8MDefining the mechanisms of hemoglobin switching and genotoxicities associated with its manipulationK01DK132453 · NIDDK · VERSITI BLOOD HEALTH, INC. · PI Phillip A Doerfler · 2022 to 2026
$760kMapping Gamma Globin Regulatory ElementsF32DK118822 · NIDDK · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DOERFLER, PHILLIP A · 2018 to 2020
$192kNCI NIH HHS P30 CA021765NCI NIH HHS R35 CA220483NHLBI NIH HHS P01 HL053749NHLBI NIH HHS R01 HL119479NHLBI NIH HHS R01 HL156647NIDDK NIH HHS F32 DK118822NIDDK NIH HHS K01 DK132453NIDDK NIH HHS R24 DK106766
Abstract
Around birth, globin expression in human red blood cells (RBCs) shifts from γ-globin to β-globin, which results in fetal haemoglobin (HbF, α
Indexed as
gamma-GlobinsAryl Hydrocarbon Receptor Nuclear TranslocatorChromatinErythropoiesisFetal HemoglobinHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitProlyl HydroxylasesProteasome Endopeptidase ComplexRNA, Long NoncodingUbiquitinUbiquitin-Protein LigasesVon Hippel-Lindau Tumor Suppressor ProteinARNT protein, humanAryl Hydrocarbon Receptor Nuclear TranslocatorChromatinFetal Hemoglobingamma-GlobinsHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitProlyl HydroxylasesProteasome Endopeptidase ComplexRNA, Long NoncodingUbiquitinUbiquitin-Protein LigasesVHL protein, humanVon Hippel-Lindau Tumor Suppressor Protein
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