Evidence map›Paper›PMID 36224029›Full record

ArticleNeurology2023

Association Between Dietary Habits in Midlife With Dementia Incidence Over a 20-Year Period.

Isabelle Glans, Emily Sonestedt, Katarina Nägga, Anna-Märta Gustavsson, Esther González-Padilla, Yan Borne, Erik Stomrud, Olle Melander, Peter M Nilsson, Sebastian Palmqvist and 1 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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  10. Associations between the EAT-Lancet planetary health diet and incident dementia.The journal of prevention of Alzheimer's disease · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Isabelle GlansFrom the Clinical Memory Research Unit (I.G., K.N., A.-M.G., Erik Stomrud, S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic (I.G., A.-M.G., Erik Stomrud, S.P., O.H.), Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences in Malmö(Emily Sonestedt, E.G.-P., Y.B.), Nutritional Epidemiology, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Acute Internal Medicine and Geriatrics (K.N.), Linköping University, Sweden; and Department of Clinical Sciences Malmö (O.M., P.M.N.), Lund University, Skåne University Hospital, Malmö, Sweden. isabelle.glans@med.lu.se.
Emily SonestedtFrom the Clinical Memory Research Unit (I.G., K.N., A.-M.G., Erik Stomrud, S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic (I.G., A.-M.G., Erik Stomrud, S.P., O.H.), Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences in Malmö(Emily Sonestedt, E.G.-P., Y.B.), Nutritional Epidemiology, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Acute Internal Medicine and Geriatrics (K.N.), Linköping University, Sweden; and Department of Clinical Sciences Malmö (O.M., P.M.N.), Lund University, Skåne University Hospital, Malmö, Sweden.
Katarina NäggaFrom the Clinical Memory Research Unit (I.G., K.N., A.-M.G., Erik Stomrud, S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic (I.G., A.-M.G., Erik Stomrud, S.P., O.H.), Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences in Malmö(Emily Sonestedt, E.G.-P., Y.B.), Nutritional Epidemiology, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Acute Internal Medicine and Geriatrics (K.N.), Linköping University, Sweden; and Department of Clinical Sciences Malmö (O.M., P.M.N.), Lund University, Skåne University Hospital, Malmö, Sweden.
Anna-Märta GustavssonFrom the Clinical Memory Research Unit (I.G., K.N., A.-M.G., Erik Stomrud, S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic (I.G., A.-M.G., Erik Stomrud, S.P., O.H.), Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences in Malmö(Emily Sonestedt, E.G.-P., Y.B.), Nutritional Epidemiology, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Acute Internal Medicine and Geriatrics (K.N.), Linköping University, Sweden; and Department of Clinical Sciences Malmö (O.M., P.M.N.), Lund University, Skåne University Hospital, Malmö, Sweden.
Esther González-PadillaFrom the Clinical Memory Research Unit (I.G., K.N., A.-M.G., Erik Stomrud, S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic (I.G., A.-M.G., Erik Stomrud, S.P., O.H.), Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences in Malmö(Emily Sonestedt, E.G.-P., Y.B.), Nutritional Epidemiology, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Acute Internal Medicine and Geriatrics (K.N.), Linköping University, Sweden; and Department of Clinical Sciences Malmö (O.M., P.M.N.), Lund University, Skåne University Hospital, Malmö, Sweden.
Yan BorneFrom the Clinical Memory Research Unit (I.G., K.N., A.-M.G., Erik Stomrud, S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic (I.G., A.-M.G., Erik Stomrud, S.P., O.H.), Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences in Malmö(Emily Sonestedt, E.G.-P., Y.B.), Nutritional Epidemiology, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Acute Internal Medicine and Geriatrics (K.N.), Linköping University, Sweden; and Department of Clinical Sciences Malmö (O.M., P.M.N.), Lund University, Skåne University Hospital, Malmö, Sweden.
Erik StomrudFrom the Clinical Memory Research Unit (I.G., K.N., A.-M.G., Erik Stomrud, S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic (I.G., A.-M.G., Erik Stomrud, S.P., O.H.), Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences in Malmö(Emily Sonestedt, E.G.-P., Y.B.), Nutritional Epidemiology, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Acute Internal Medicine and Geriatrics (K.N.), Linköping University, Sweden; and Department of Clinical Sciences Malmö (O.M., P.M.N.), Lund University, Skåne University Hospital, Malmö, Sweden.
Olle MelanderFrom the Clinical Memory Research Unit (I.G., K.N., A.-M.G., Erik Stomrud, S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic (I.G., A.-M.G., Erik Stomrud, S.P., O.H.), Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences in Malmö(Emily Sonestedt, E.G.-P., Y.B.), Nutritional Epidemiology, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Acute Internal Medicine and Geriatrics (K.N.), Linköping University, Sweden; and Department of Clinical Sciences Malmö (O.M., P.M.N.), Lund University, Skåne University Hospital, Malmö, Sweden.
Peter M NilssonFrom the Clinical Memory Research Unit (I.G., K.N., A.-M.G., Erik Stomrud, S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic (I.G., A.-M.G., Erik Stomrud, S.P., O.H.), Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences in Malmö(Emily Sonestedt, E.G.-P., Y.B.), Nutritional Epidemiology, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Acute Internal Medicine and Geriatrics (K.N.), Linköping University, Sweden; and Department of Clinical Sciences Malmö (O.M., P.M.N.), Lund University, Skåne University Hospital, Malmö, Sweden.ORCID 0000-0002-5652-8459
Sebastian PalmqvistFrom the Clinical Memory Research Unit (I.G., K.N., A.-M.G., Erik Stomrud, S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic (I.G., A.-M.G., Erik Stomrud, S.P., O.H.), Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences in Malmö(Emily Sonestedt, E.G.-P., Y.B.), Nutritional Epidemiology, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Acute Internal Medicine and Geriatrics (K.N.), Linköping University, Sweden; and Department of Clinical Sciences Malmö (O.M., P.M.N.), Lund University, Skåne University Hospital, Malmö, Sweden.
Oskar HanssonFrom the Clinical Memory Research Unit (I.G., K.N., A.-M.G., Erik Stomrud, S.P., O.H.), Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic (I.G., A.-M.G., Erik Stomrud, S.P., O.H.), Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences in Malmö(Emily Sonestedt, E.G.-P., Y.B.), Nutritional Epidemiology, Lund University, Skåne University Hospital, Malmö, Sweden; Department of Acute Internal Medicine and Geriatrics (K.N.), Linköping University, Sweden; and Department of Clinical Sciences Malmö (O.M., P.M.N.), Lund University, Skåne University Hospital, Malmö, Sweden.
Skåne University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesDementia cases are expected to triple during the next 30 years, highlighting the importance of finding modifiable risk factors for dementia. The aim of this study was to investigate whether adherence to conventional dietary recommendations or to a modified Mediterranean diet are associated with a subsequent lower risk of developing all-cause dementia, Alzheimer disease (AD), vascular dementia (VaD), or with future accumulation of AD-related β-amyloid (Aβ) pathology.

methodsBaseline examination in the prospective Swedish population-based Malmö Diet and Cancer Study took place in 1991-1996 with a follow-up for incident dementia until 2014. Nondemented individuals born 1923-1950 and living in Malmö were invited to participate. Thirty thousand four hundred forty-six were recruited (41% of all eligible). Twenty-eight thousand twenty-five had dietary data and were included in this study. Dietary habits were assessed with a 7-day food diary, detailed food frequency questionnaire, and 1-hour interview. Main outcomes were incident all-cause dementia, AD, or VaD determined by memory clinic physicians. Secondary outcome was Aβ-accumulation measured using CSF Aβ42 (n = 738). Cox proportional hazard models were used to examine associations between diet and risk of developing dementia (adjusted for demographics, comorbidities, smoking, physical activity, and alcohol).

resultsSixty-one percent were women, and the mean (SD) age was 58.1 (7.6) years. One thousand nine hundred forty-three (6.9%) were diagnosed with dementia (median follow-up, 19.8 years). Individuals adhering to conventional dietary recommendations did not have lower risk of developing all-cause dementia (hazard ratio [HR] comparing worst with best adherence, 0.93, 95% CI 0.81-1.08), AD (HR 1.03, 0.85-1.23), or VaD (HR 0.93, 0.69-1.26). Neither did adherence to the modified Mediterranean diet lower the risk of developing all-cause dementia (HR 0.93 0.75-1.15), AD (HR 0.90, 0.68-1.19), or VaD (HR 1.00, 0.65-1.55). The results were similar when excluding participants developing dementia within 5 years or those with diabetes. No significant associations were found between diet and abnormal Aβ accumulation, conventional recommendations (OR 1.28, 0.74-2.24) or modified Mediterranean diet (OR 0.85, 0.39-1.84). DISCUSSION: In this 20-year follow-up study, neither adherence to conventional dietary recommendations nor to modified Mediterranean diet were significantly associated with subsequent reduced risk for developing all-cause dementia, AD dementia, VaD, or AD pathology.

Indexed as

Alzheimer DiseaseDementia, VascularDiet, MediterraneanFeeding BehaviorFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedProspective StudiesRisk Factors

Identifiers

PMID36224029
PMCPMC9827131
OpenAlexW4304809056

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.