Evidence map›Paper›PMID 36223935›Full record

ArticleCanadian journal of surgery. Journal canadien de chirurgie

Trends in liver transplantation for autoimmune liver diseases: a Canadian study.

Carla F Murillo Perez, Tommy Ivanics, Marco P A W Claasen, Peter Yoon, David Wallace, Nazia Selzner, Gideon M Hirschfield, Bettina E Hansen, Gonzalo Sapisochin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of surgery. Journal canadien de chirurgie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Outcome of Liver Retransplantation in Patients With Primary Sclerosing Cholangitis.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 6 countries.

Carla F Murillo PerezFrom the Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Ont. (Murillo Perez, Hirschfield, Hansen); the Multi-Organ Transplant Program, University Health Network, Toronto, Ont. (Ivanics, Claasen, Yoon, Wallace, Selzner, Sapisochin); the Department of Surgery, Henry Ford Hospital, Detroit, Mich. (Ivanics); the Department of Surgical Sciences, Akademiska sjukhuset, Uppsala University, Uppsala, Sweden (Ivanics); the Department of Surgery, Erasmus MC, University Medical Center Rotterdam, the Netherlands (Claasen); the Department of Surgery, Westmead Hospital, Sydney, Australia (Yoon); the Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK (Wallace); the Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK (Wallace); and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ont. (Hansen).
Tommy IvanicsFrom the Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Ont. (Murillo Perez, Hirschfield, Hansen); the Multi-Organ Transplant Program, University Health Network, Toronto, Ont. (Ivanics, Claasen, Yoon, Wallace, Selzner, Sapisochin); the Department of Surgery, Henry Ford Hospital, Detroit, Mich. (Ivanics); the Department of Surgical Sciences, Akademiska sjukhuset, Uppsala University, Uppsala, Sweden (Ivanics); the Department of Surgery, Erasmus MC, University Medical Center Rotterdam, the Netherlands (Claasen); the Department of Surgery, Westmead Hospital, Sydney, Australia (Yoon); the Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK (Wallace); the Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK (Wallace); and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ont. (Hansen).
Marco P A W ClaasenFrom the Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Ont. (Murillo Perez, Hirschfield, Hansen); the Multi-Organ Transplant Program, University Health Network, Toronto, Ont. (Ivanics, Claasen, Yoon, Wallace, Selzner, Sapisochin); the Department of Surgery, Henry Ford Hospital, Detroit, Mich. (Ivanics); the Department of Surgical Sciences, Akademiska sjukhuset, Uppsala University, Uppsala, Sweden (Ivanics); the Department of Surgery, Erasmus MC, University Medical Center Rotterdam, the Netherlands (Claasen); the Department of Surgery, Westmead Hospital, Sydney, Australia (Yoon); the Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK (Wallace); the Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK (Wallace); and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ont. (Hansen).
Peter YoonFrom the Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Ont. (Murillo Perez, Hirschfield, Hansen); the Multi-Organ Transplant Program, University Health Network, Toronto, Ont. (Ivanics, Claasen, Yoon, Wallace, Selzner, Sapisochin); the Department of Surgery, Henry Ford Hospital, Detroit, Mich. (Ivanics); the Department of Surgical Sciences, Akademiska sjukhuset, Uppsala University, Uppsala, Sweden (Ivanics); the Department of Surgery, Erasmus MC, University Medical Center Rotterdam, the Netherlands (Claasen); the Department of Surgery, Westmead Hospital, Sydney, Australia (Yoon); the Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK (Wallace); the Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK (Wallace); and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ont. (Hansen).
David WallaceFrom the Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Ont. (Murillo Perez, Hirschfield, Hansen); the Multi-Organ Transplant Program, University Health Network, Toronto, Ont. (Ivanics, Claasen, Yoon, Wallace, Selzner, Sapisochin); the Department of Surgery, Henry Ford Hospital, Detroit, Mich. (Ivanics); the Department of Surgical Sciences, Akademiska sjukhuset, Uppsala University, Uppsala, Sweden (Ivanics); the Department of Surgery, Erasmus MC, University Medical Center Rotterdam, the Netherlands (Claasen); the Department of Surgery, Westmead Hospital, Sydney, Australia (Yoon); the Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK (Wallace); the Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK (Wallace); and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ont. (Hansen).
Nazia SelznerFrom the Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Ont. (Murillo Perez, Hirschfield, Hansen); the Multi-Organ Transplant Program, University Health Network, Toronto, Ont. (Ivanics, Claasen, Yoon, Wallace, Selzner, Sapisochin); the Department of Surgery, Henry Ford Hospital, Detroit, Mich. (Ivanics); the Department of Surgical Sciences, Akademiska sjukhuset, Uppsala University, Uppsala, Sweden (Ivanics); the Department of Surgery, Erasmus MC, University Medical Center Rotterdam, the Netherlands (Claasen); the Department of Surgery, Westmead Hospital, Sydney, Australia (Yoon); the Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK (Wallace); the Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK (Wallace); and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ont. (Hansen).
Gideon M HirschfieldFrom the Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Ont. (Murillo Perez, Hirschfield, Hansen); the Multi-Organ Transplant Program, University Health Network, Toronto, Ont. (Ivanics, Claasen, Yoon, Wallace, Selzner, Sapisochin); the Department of Surgery, Henry Ford Hospital, Detroit, Mich. (Ivanics); the Department of Surgical Sciences, Akademiska sjukhuset, Uppsala University, Uppsala, Sweden (Ivanics); the Department of Surgery, Erasmus MC, University Medical Center Rotterdam, the Netherlands (Claasen); the Department of Surgery, Westmead Hospital, Sydney, Australia (Yoon); the Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK (Wallace); the Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK (Wallace); and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ont. (Hansen).
Bettina E HansenFrom the Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Ont. (Murillo Perez, Hirschfield, Hansen); the Multi-Organ Transplant Program, University Health Network, Toronto, Ont. (Ivanics, Claasen, Yoon, Wallace, Selzner, Sapisochin); the Department of Surgery, Henry Ford Hospital, Detroit, Mich. (Ivanics); the Department of Surgical Sciences, Akademiska sjukhuset, Uppsala University, Uppsala, Sweden (Ivanics); the Department of Surgery, Erasmus MC, University Medical Center Rotterdam, the Netherlands (Claasen); the Department of Surgery, Westmead Hospital, Sydney, Australia (Yoon); the Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK (Wallace); the Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK (Wallace); and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ont. (Hansen).
Gonzalo SapisochinFrom the Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Ont. (Murillo Perez, Hirschfield, Hansen); the Multi-Organ Transplant Program, University Health Network, Toronto, Ont. (Ivanics, Claasen, Yoon, Wallace, Selzner, Sapisochin); the Department of Surgery, Henry Ford Hospital, Detroit, Mich. (Ivanics); the Department of Surgical Sciences, Akademiska sjukhuset, Uppsala University, Uppsala, Sweden (Ivanics); the Department of Surgery, Erasmus MC, University Medical Center Rotterdam, the Netherlands (Claasen); the Department of Surgery, Westmead Hospital, Sydney, Australia (Yoon); the Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK (Wallace); the Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK (Wallace); and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ont. (Hansen) Gonzalo.sapisochin@uhn.ca.
Erasmus MC · NLUppsala University Hospital · SEKing's College Hospital NHS Foundation Trust · GBLondon School of Hygiene & Tropical Medicine · GBToronto General Hospital · CAUniversity of Toronto · CAWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo our knowledge, no analysis of data from liver transplantation registries exists in Canada. We aimed to describe temporal trends in the number of liver transplantation procedures, patient characteristics and posttransplantation outcomes for autoimmune liver diseases (AILDs) in Canada.

methodsWe used administrative data from the Canadian Organ Replacement Register, which contains liver transplantation information from 6 centres in Canada. This study included transplantation information from 5 of the centres, as liver transplantation procedures in children were not included. We included adult (age ≥ 18 yr) patients with a diagnosis of primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH) or overlap syndrome (PBC-AIH or PSC-AIH) who received a liver transplant from 2000 to 2018.

resultsOf 5722 primary liver transplantation procedures performed over the study period, 1070 (18.7%) were for an AILD: 489 (45.7%) for PSC, 341 (31.9%) for PBC, 220 (20.6%) for AIH and 20 (1.9%) for overlap syndrome. There was a significant increase in the absolute number of procedures for PSC, with a yearly increase of 0.6 (95% confidence interval 0.1 to 1.2), whereas the absolute number of procedures for PBC and AIH remained stable. The proportion of transplantation procedures decreased for PBC and AIH but remained stable for PSC. Recipient age at transplantation increased over time for males with PBC (median 53 yr in 2000-2005 to 57 yr in 2012-2018,

conclusionBetween 2000 and 2018, the absolute number of liver transplantation procedures in Canada increased for PSC but remained stable for PBC and AIH; proportionally, PBC and AIH decreased as indications for transplantation. Posttransplantation survival improved only for the PBC group. An improved understanding of trends and outcomes on a national scale among patients with AILD undergoing liver transplantation can identify disparities and areas for potential health care improvement.

Indexed as

Cholangitis, SclerosingHepatitis, AutoimmuneLiver Cirrhosis, BiliaryLiver DiseasesLiver TransplantationAdultCanadaChildHumansMaleMiddle Aged

Identifiers

PMID36223935
PMCPMC9564189
OpenAlexW4304692084

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.