Evidence map›Paper›PMID 36223775›Full record

ArticleCurrent biology : CB2022

Co-opted genes of algal origin protect C. elegans against cyanogenic toxins.

Bingying Wang, Taruna Pandey, Yong Long, Sofia E Delgado-Rodriguez, Matthew D Daugherty, Dengke K Ma

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Suppressing APOE4-induced mortality and cellular damage by targeting VHL.bioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Bingying WangCardiovascular Research Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Taruna PandeyCardiovascular Research Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Yong LongState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Sofia E Delgado-RodriguezDepartment of Molecular Biology, University of California, San Diego, San Diego, CA, USA.
Matthew D DaughertyDepartment of Molecular Biology, University of California, San Diego, San Diego, CA, USA. Electronic address: mddaugherty@ucsd.edu.
Dengke K MaCardiovascular Research Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA, USA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. Electronic address: dengke.ma@ucsf.edu.
University of California, San Francisco · USUniversity of California San Diego · USChinese Academy of Sciences · CN

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Pathogen-driven evolution of innate antiviral defense mechanismsR35GM133633 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty · 2019 to 2026
$3.3M
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermiaR35GM139618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Dengke Ma · 2021 to 2026
$2.3M
NIGMS NIH HHS R35 GM133633NIGMS NIH HHS R35 GM139618NIH HHS P40 OD010440
6 · The paper itself

Abstract

Amygdalin is a cyanogenic glycoside enriched in the tissues of many edible plants, including seeds of stone fruits such as cherry (Prunus avium), peach (Prunus persica), and apple (Malus domestica). These plants biosynthesize amygdalin in defense against herbivore animals, as amygdalin generates poisonous cyanide upon plant tissue destruction.

Indexed as

AmygdalinCaenorhabditis elegans ProteinsAnimalsCaenorhabditis elegansCyanidesPhylogenyAmygdalinCaenorhabditis elegans ProteinsCyanidesamygdalinC. eleganscyanide detoxifcationcysl-1cysl-2EGL-9gene co-optiongreen algaeHIF-1horizontal gene transfer

Identifiers

PMID36223775
PMCPMC9691542
OpenAlexW4304196341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.