ArticleNeuroepidemiology2022
Epidemiology of First and Recurrent Ischemic Stroke in Sweden 2010-2019: A Riksstroke Study.
Article in Neuroepidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Effects of cognitive-motor interventions on serum BDNF levels in adults and older population post-stroke: a systematic review and meta-analysis of randomized controlled trials.Frontiers in pharmacology · 2026Pooled it
- Percutaneous closure of patent foramen ovale after cryptogenic stroke - a comparison between patients < 60 versus ≥ 60 years-of-age.Cardiovascular intervention and therapeutics · 2026Article
- Risk of recurrent ischemic stroke after non-cardioembolic ischemic stroke in England and Denmark.Journal of neurology · 2026Article
- Two Decades of Declining Stroke Burden in Kaunas, Lithuania (2000-2023): A Population-Based Analysis of Morbidity, Mortality, and Case-Fatality Trends by Sex, Age, and Stroke Type.Medicina (Kaunas, Lithuania) · 2026Article
- Trends in Antithrombotic Therapy Initiation Among Patients With Stroke Pre- and Post-COVID-19 in Sweden-An Interrupted Time Series Study.Basic & clinical pharmacology & toxicology · 2026Article
- Temporal changes in functional outcome and case-fatality after ischaemic stroke and intracerebral haemorrhage in Sweden 2010-2019: an observational study from the Swedish Stroke Register (Riksstroke).European stroke journal · 2026Observational
- Stroke Action Plan for Europe 2018-2030 (SAP-E): mid-term review and update.European stroke journal · 2026Review
- Seizure recurrence after first epileptic episode in ischemic stroke: Risk factors and their association with cognition and mood.World journal of psychiatry · 2025Article
- Direct medical cost of first-ever acute ischemic stroke in malaysia: a retrospective cohort study.Scientific reports · 2025Article
- Current trends in stroke events, mortality, and case fatality in Switzerland: an epidemiologic update.International journal of epidemiology · 2025Article
- Serum Insulin-like Growth Factor-II Is Associated with Poor Poststroke Outcomes in Males: A Secondary Analysis.International journal of molecular sciences · 2025Article
- Risk of Ischemic and Hemorrhagic Stroke in Individuals With Type 1 and Type 2 Diabetes: A Nationwide Cohort Study in Sweden.Neurology · 2025Article
- Article
- Number of Previous Strokes and the Association With Clinical Outcomes of Patients With Atrial Fibrillation: Longitudinal Data From the GLORIA-AF Registry.Journal of the American Heart Association · 2025Article
- Clinical applications of artificial intelligence and machine learning in neurocardiology: a comprehensive review.Frontiers in cardiovascular medicine · 2025Review
- Temporal Trends in Mortality Related to Stroke and Atrial Fibrillation in the United States: A 21-Year Retrospective Analysis of CDC-WONDER Database.Clinical cardiology · 2024Article
- Symptoms at stroke onset as described by patients: a qualitative study.BMC neurology · 2024Article
- Plasma lipidomic profiling reveals six candidate biomarkers for the prediction of incident stroke in patients with hypertension.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization-Lancet Neurology Commission.The Lancet. Neurology · 2023Review
- Delivery of acute ischaemic stroke treatments in the European region in 2019 and 2020.European stroke journal · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIschemic stroke incidence appears to have decreased during the last decades, but most studies focus on the first-ever events and epidemiological data on recurrent stroke are scarce. The aim of our study was to investigate trends in incidence, risk factors, and medication in patients with first-ever and recurrent ischemic stroke between 2010 and 2019 in Sweden.
methodsWe included patients (≥18 years old) with ischemic stroke registered in the hospital-based Swedish Stroke Register (Riksstroke) 2010-2019. The coverage of Riksstroke was consistently high (about 90%) during this period. Data were stratified by first-ever and recurrent ischemic stroke in three different time periods (2010-2012, 2013-2016, and 2017-2019) and shown as crude and age-specific incidence rates per 100,000 person-years. Statistics Sweden provided census data on the Swedish population in different age groups.
resultsDuring the study period, 201,316 cases of ischemic stroke were registered in Riksstroke, including 153,865 (76.4%) cases of first-ever ischemic stroke and 46,248 (23.0%) cases of recurrent ischemic stroke (0.6% of cases unclassified). The crude incidence of first-ever ischemic stroke decreased by 17% from 216 (95% CI 214-218) to 179 (95% CI 177-181) between 2010-2012 and 2017-2019, whereas recurrent ischemic stroke decreased by 33% from 72 (95% CI 71-73) to 48 (95% CI 47-49). Between these time periods, diminishing ischemic stroke incidence was seen in all age groups with highest decline noted in those aged 75-84 years (928 [95% CI 914-943] to 698 [95% CI 686-709]; -25% in first-ever ischemic stroke and 361 [95% CI 351-370] to 219 [95% CI 213-226]; -39% in recurrent ischemic stroke) and ≥85 years (1,674 [95% CI 1,645-1,703] to 1,295 [95% CI 1,270-1,320]; -23% in first-ever ischemic stroke and 683 [95% CI 664-702] to 423 [95% CI 409-437]; -38% in recurrent ischemic stroke). Treatment with anticoagulants in patients with atrial fibrillation and lipid-lowering drugs increased considerably in patients with first-ever and recurrent ischemic stroke both at admission and discharge during the study period.
conclusionWhereas both first-ever and recurrent ischemic stroke rates declined in Sweden between 2010 and 2019, the proportional decline was almost double for recurrent ischemic stroke than for first-ever ischemic stroke and most pronounced in the elderly. Increased use of secondary preventive drugs, in particular anticoagulants in atrial fibrillation, appears to have contributed, but further studies on precise causes for the decline in recurrent ischemic stroke are needed.
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