Evidence map›Paper›PMID 36223744›Full record

ArticleCell reports2022

Maternal gut microbiota mediate intergenerational effects of high-fat diet on descendant social behavior.

Claudia M Di Gesù, Lisa M Matz, Ian J Bolding, Robert Fultz, Kristi L Hoffman, Antonella Marino Gammazza, Joseph F Petrosino, Shelly A Buffington

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Claudia M Di GesùDepartment of Neurobiology, The University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.
Lisa M MatzDepartment of Neurobiology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Ian J BoldingDepartment of Neurobiology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Robert FultzDepartment of Neurobiology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Kristi L HoffmanAlkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Antonella Marino GammazzaDepartment of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.
Joseph F PetrosinoAlkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Shelly A BuffingtonDepartment of Neurobiology, The University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Center for Microbiome Research, The University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: shbuffin@utmb.edu.
The University of Texas Medical Branch at Galveston · USBaylor College of Medicine · USUniversity of Palermo · IT

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Translational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2019 to 2026
$14.7M
Targeting opportunistic pathogens to improve maternal obesity-associated health outcomes in offspringR01HD109095 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Shelly A Buffington · 2022 to 2026
$2.4M
Predoctoral and Postdoctoral Training in Alzheimer's PathophysiologyT32AG067952 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI KAYED, RAKEZ · 2021 to 2025
$1.5M
NIA NIH HHS T32 AG067952NICHD NIH HHS R01 HD109095NIDDK NIH HHS P30 DK056338NIEHS NIH HHS P30 ES030285
6 · The paper itself

Abstract

Dysbiosis of the maternal gut microbiome during pregnancy is associated with adverse neurodevelopmental outcomes. We previously showed that maternal high-fat diet (MHFD) in mice induces gut dysbiosis, social dysfunction, and underlying synaptic plasticity deficits in male offspring (F

Indexed as

Diet, High-FatGastrointestinal MicrobiomeAnimalsDysbiosisFemaleMaleMicePregnancySocial BehaviorCP: MicrobiologyCP: NeuroscienceDOHaDintergenerationalLimosilactobacillus reuterimaternal dietmicrobiomeneurodevelopmentprobioticssocial behavior

Identifiers

PMID36223744
PMCPMC9597666
OpenAlexW4304608958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.