Evidence map›Paper›PMID 36223665›Full record

ReviewJournal of chromatography. A2022

Nanofluidic devices for the separation of biomolecules.

Chathurika Rathnayaka, Charuni A Amarasekara, Khurshed Akabirov, Michael C Murphy, Sunggook Park, Malgorzata A Witek, Steven A Soper

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of chromatography. A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chathurika RathnayakaDepartment of Chemistry, The University of Kansas, Lawrence, KS 66045, USA; Center of BioModular Multiscale Systems for Precision Medicine, USA.
Charuni A AmarasekaraDepartment of Chemistry, The University of Kansas, Lawrence, KS 66045, USA; Center of BioModular Multiscale Systems for Precision Medicine, USA.
Khurshed AkabirovDepartment of Chemistry, The University of Kansas, Lawrence, KS 66045, USA; Center of BioModular Multiscale Systems for Precision Medicine, USA.
Michael C MurphyCenter of BioModular Multiscale Systems for Precision Medicine, USA; Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70810, USA.
Sunggook ParkCenter of BioModular Multiscale Systems for Precision Medicine, USA; Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70810, USA.
Malgorzata A WitekDepartment of Chemistry, The University of Kansas, Lawrence, KS 66045, USA; Center of BioModular Multiscale Systems for Precision Medicine, USA.
Steven A SoperDepartment of Chemistry, The University of Kansas, Lawrence, KS 66045, USA; Center of BioModular Multiscale Systems for Precision Medicine, USA; Department of Mechanical Engineering, The University of Kansas, Lawrence, KS 66045, USA; Bioengineering Program, The University of Kansas, Lawrence, KS 66045, USA; KU Cancer Center and Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA. Electronic address: ssoper@ku.edu.

Funding

Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Kalyani Pyaram, Steven Allan Soper · 2019 to 2026
$21.5M
Single-Molecule Processing: Detection and Identification of Single DNAs, RNAs, and Proteins using Immobilized Nanoscale Enzymatic Reactors (INERs) and Nanoscale ElectrophoresisP41EB020594 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Sunggook Park · 2015 to 2026
$15.2M
NIBIB NIH HHS P41 EB020594NIGMS NIH HHS P20 GM130423
6 · The paper itself

Abstract

Over the last 30-years, microchip electrophoresis and its applications have expanded due to the benefits it offers. Nanochip electrophoresis, on the other hand, is viewed as an evolving area of electrophoresis because it offers some unique advantages not associated with microchip electrophoresis. These advantages arise from unique phenomena that occur in the nanometer domain not readily apparent in the microscale domain due to scale-dependent effects. Scale-dependent effects associated with nanochip electrophoresis includes high surface area-to-volume ratio, electrical double layer overlap generating parabolic flow even for electrokinetic pumping, concentration polarization, transverse electromigration, surface charge dominating flow, and surface roughness. Nanochip electrophoresis devices consist of channels with dimensions ranging from 1 to 1000 nm including classical (1-100 nm) and extended (100 nm - 1000 nm) nanoscale devices. In this review, we highlight scale-dependent phenomena associated with nanochip electrophoresis and the utilization of those phenomena to provide unique biomolecular separations that are not possible with microchip electrophoresis. We will also review the range of materials used for nanoscale separations and the implication of material choice for the top-down fabrication and operation of these devices. We will also provide application examples of nanochip electrophoresis for biomolecule separations with an emphasis on nano-electrophoresis (nEP) and nano-electrochromatography (nEC).

Indexed as

Electrophoresis, MicrochipElectrical double layer overlapNanoscale electrophoresisPlastic columnsSingle-molecule DNA sequencing

Identifiers

PMID36223665
PMCPMC9795076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.