Evidence map›Paper›PMID 36223521›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2022

Metabolic labeling unveils alterations in the turnover of HDL-associated proteins during diabetes progression in mice.

Prabodh Sadana, Melissa Edler, Mirjavid Aghayev, Andrea Arias-Alvarado, Emilie Cohn, Serguei Ilchenko, Helen Piontkivska, Jagan A Pillai, Sangeeta Kashyap, Takhar Kasumov

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Prabodh SadanaDepartment of Pharmacy Practice, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio.
Melissa EdlerDepartment of Anthropology, Kent State University, Kent, Ohio.
Mirjavid AghayevDepartment of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio.
Andrea Arias-AlvaradoDepartment of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio.
Emilie CohnDepartment of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio.
Serguei IlchenkoDepartment of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio.
Helen PiontkivskaDepartment of Biological Sciences, and Brain Health Research Institute, Kent State University, Kent, Ohio.
Jagan A PillaiLou Ruvo Center for Brain Health, Cleveland Clinic Foundation, Cleveland, Ohio.
Sangeeta KashyapDepartment of Endocrinology, Cleveland Clinic, Cleveland, Ohio.
Takhar KasumovDepartment of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio.ORCID 0000-0003-2173-7231
Northeast Ohio Medical University · USCleveland Clinic · USKent State University · US

Funding

NIDDK Network Coordinating UnitU24DK097771 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Shuibing Chen, Jeffrey S. Grethe · 2013 to 2026
$20.9M
Project Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent MechanismP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI LAURA E. NAGY · 2016 to 2026
$19.6M
Follistatin-like protein 1 in cardiac and systemic metabolismR01HL129120 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RECCHIA, FABIO A, WALSH, KENNETH · 2016 to 2019
$2.9M
Novel computational methods for in vivo proteome dynamics estimation using heavy water metabolic labeling and LC-MSR01GM112044 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SADYGOV, ROVSHAN G · 2015 to 2023
$2.7M
NHLBI NIH HHS R01 HL129120NIAAA NIH HHS P50 AA024333NIDDK NIH HHS U24 DK097771NIGMS NIH HHS R01 GM112044
6 · The paper itself

Abstract

Several aspects of diabetes pathophysiology and complications result from hyperglycemia-induced alterations in the structure and function of plasma proteins. Furthermore, insulin has a significant influence on protein metabolism by affecting both the synthesis and degradation of proteins in various tissues. To understand the role of progressive hyperglycemia on plasma proteins, in this study, we measured the turnover rates of high-density lipoprotein (HDL)-associated proteins in control (chow diet), prediabetic [a high-fat diet (HFD) for 8 wk] or diabetic [HFD for 8 wk with low-dose streptozotocin (HFD + STZ) in

Indexed as

Diabetes Mellitus, ExperimentalHyperglycemiaPrediabetic StateAnimalsBlood GlucoseDiet, High-FatDisease ProgressionLipoproteins, HDLMiceMice, Inbred C57BLProteomeStreptozocinBlood GlucoseLipoproteins, HDLProteomeStreptozocinHDLheavy watermass spectrometryproteomicstype 2 diabetes

Identifiers

PMID36223521
PMCPMC9722254
OpenAlexW4304731646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.