Evidence map›Paper›PMID 36223472›Full record

ArticleScience advances2022

Mindfulness-induced endogenous theta stimulation occasions self-transcendence and inhibits addictive behavior.

Eric L Garland, Adam W Hanley, Justin Hudak, Yoshio Nakamura, Brett Froeliger

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Major depressive disorder-alcohol use disorder comorbidity: diagnosis, mechanisms and treatment.European archives of psychiatry and clinical neuroscience · 2026
    Review
  3. Nondual Awareness as a Novel Chronic Pain Relieving Mechanism.Psychology of consciousness (Washington, D.C.) · 2026
    Article
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  7. Review
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  15. Review
  16. Article
  17. Searching for biomarkers in the fluidity of mental ill-health.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023
    Article
  18. Article
  19. Article
  20. The (In)flexible self: Psychopathology, mindfulness, and neuroscience.International journal of clinical and health psychology : IJCHP
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Eric L GarlandCenter on Mindfulness and Integrative Health Intervention Development, College of Social Work, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-2891-857X
Adam W HanleyCenter on Mindfulness and Integrative Health Intervention Development, College of Social Work, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0001-8965-6898
Justin HudakCenter on Mindfulness and Integrative Health Intervention Development, College of Social Work, University of Utah, Salt Lake City, UT, USA.
Yoshio NakamuraDepartment of Anesthesiology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Brett FroeligerDepartment of Psychology, University of Missouri, Columbia, MO, USA.
University of Utah · USUniversity of Missouri · US

Funding

Targeting Hedonic Dysregulation to Address Chronic Pain and Opioid Misuse in Primary Care.R01DA042033 · NIDA · UNIVERSITY OF UTAH · PI GARLAND, ERIC LEE · 2016 to 2020
$2.8M
Neural mechanisms mediating appetitive regulation and smoking in nicotine addictionR01DA048094 · NIDA · UNIVERSITY OF MISSOURI-COLUMBIA · PI FROELIGER, BRETT, GARLAND, ERIC LEE · 2019 to 2023
$2.2M
Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment for Opioid Use and Chronic Pain ManagementR33AT010109 · NCCIH · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI COOPERMAN, NINA · 2019 to 2020
$1.5M
Effects of Mindfulness-Oriented Intervention on Endogenous Opioid Mechanisms of Hedonic Regulation in Chronic Pain.R61AT009296 · NCCIH · UNIVERSITY OF UTAH · PI GARLAND, ERIC LEE, ZUBIETA, JON-KAR · 2016 to 2017
$831k
NCCIH NIH HHS R33 AT010109NCCIH NIH HHS R61 AT009296NIDA NIH HHS R01 DA042033NIDA NIH HHS R01 DA048094
6 · The paper itself

Abstract

Self-regulation is instantiated by theta oscillations (4 to 8 Hz) in neurons of frontal midline brain regions. Frontal midline theta (FMΘ) is inversely associated with default mode network (DMN) activation, which subserves self-referential processing. Addiction involves impaired self-regulation and DMN dysfunction. Mindfulness is an efficacious self-regulatory practice for treating addiction, but little is known about the mechanisms by which mindfulness reduces addictive behavior. In this mechanistic study of long-term opioid users (

Identifiers

PMID36223472
PMCPMC9555770
OpenAlexW4304820425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.