Evidence map›Paper›PMID 36223394›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Stimuli-responsive vesicles as distributed artificial organelles for bacterial activation.

Ignacio Gispert, James W Hindley, Colin P Pilkington, Hansa Shree, Laura M C Barter, Oscar Ces, Yuval Elani

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Let There be Light! Light as an Engine and Regulator in Synthetic Cells.Angewandte Chemie (International ed. in English) · 2026
    Review
  3. Review
  4. A molecular grammar for programmable multiphase protein-RNA vesicles.bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Nucleated synthetic cells with genetically driven intercompartment communication.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. Magnetic Modulation of Biochemical Synthesis in Synthetic Cells.Journal of the American Chemical Society · 2024
    Article
  18. Review
  19. Review
  20. Biomimetic behaviors in hydrogel artificial cells through embedded organelles.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ignacio GispertDepartment of Chemical Engineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.ORCID 0000-0002-4100-5225
James W HindleyfabriCELL, Imperial College London, Molecular Sciences Research Hub, White City, London W12 0BZ, UK.ORCID 0000-0002-3392-4387
Colin P PilkingtonDepartment of Chemical Engineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.ORCID 0000-0002-3113-7611
Hansa ShreeDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City, London W12 0BZ, UK.
Laura M C BarterDepartment of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City, London W12 0BZ, UK.ORCID 0000-0003-2891-3509
Oscar CesfabriCELL, Imperial College London, Molecular Sciences Research Hub, White City, London W12 0BZ, UK.ORCID 0000-0002-6418-5644
Yuval ElaniDepartment of Chemical Engineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.
Imperial College London · GB

Funding

Medical Research Council MR/S031537/1
6 · The paper itself

Abstract

Intercellular communication is a hallmark of living systems. As such, engineering artificial cells that possess this behavior has been at the heart of activities in bottom-up synthetic biology. Communication between artificial and living cells has potential to confer novel capabilities to living organisms that could be exploited in biomedicine and biotechnology. However, most current approaches rely on the exchange of chemical signals that cannot be externally controlled. Here, we report two types of remote-controlled vesicle-based artificial organelles that translate physical inputs into chemical messages that lead to bacterial activation. Upon light or temperature stimulation, artificial cell membranes are activated, releasing signaling molecules that induce protein expression in

Indexed as

Artificial CellsBiological PhenomenaBacteriaOrganellesSynthetic Biologyartificial cellsartificial organellescell signalingmembranessynthetic biology

Identifiers

PMID36223394
PMCPMC9586261
OpenAlexW4304758269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.