ArticleeLife2022
Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Oscillatory co-expression of HES1 and HES5 enables a hybrid state in a cross-repressive transcription factor regulatory motif.Development (Cambridge, England) · 2026Article
- A noncanonical role of glycolytic metabolites controlling the timing of mouse embryo segmentation.Science advances · 2025Article
- Tissue-wide, synchronous Erk oscillations time the segmentation of the zebrafish notochord.bioRxiv : the preprint server for biology · 2025Article
- Progress in understanding the vertebrate segmentation clock.Nature reviews. Genetics · 2025Review
- Exploring nonlinear phenomena in animal vocalizations through oscillator theory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Acoustic frequency comb generation on a composite diamond/silicon microcantilever in ambient air.Microsystems & nanoengineering · 2025Article
- Physiological Entrainment: A Key Mind-Body Mechanism for Cognitive, Motor and Affective Functioning, and Well-Being.Brain sciences · 2024Review
- Entrainment and multi-stability of the p53 oscillator in human cells.Cell systems · 2024Article
- Article
- Nonreciprocal synchronization in embryonic oscillator ensembles.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cellular and molecular control of vertebrate somitogenesis.Nature reviews. Molecular cell biology · 2024Review
- An automated do-it-yourself system for dynamic stem cell and organoid culture in standard multi-well plates.Cell reports methods · 2022Article
- Waves in Embryonic Development.Annual review of biophysics · 2022Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Living systems exhibit an unmatched complexity, due to countless, entangled interactions across scales. Here, we aim to understand a complex system, that is, segmentation timing in mouse embryos, without a reference to these detailed interactions. To this end, we develop a coarse-grained approach, in which theory guides the experimental identification of the segmentation clock entrainment responses. We demonstrate period- and phase-locking of the segmentation clock across a wide range of entrainment parameters, including higher-order coupling. These quantifications allow to derive the phase response curve (PRC) and Arnold tongues of the segmentation clock, revealing its essential dynamical properties. Our results indicate that the somite segmentation clock has characteristics reminiscent of a highly non-linear oscillator close to an infinite period bifurcation and suggests the presence of long-term feedbacks. Combined, this coarse-grained theoretical-experimental approach reveals how we can derive simple, essential features of a highly complex dynamical system, providing precise experimental control over the pace and rhythm of the somite segmentation clock.
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