ArticleJournal of psychiatry & neuroscience : JPN
Striatal reactivity during emotion and reward relates to approach-avoidance conflict behaviour and is altered in adults with anxiety or depression.
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Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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11citing papers in PubMed, 1 pooled it
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Cholinergic system in schizophrenia: A systematic review and meta-analysis.Molecular psychiatry · 2025Pooled it
- Prediction of generalized anxiety disorder treatment outcomes with neurobehavioral responses to approach-avoidance conflict: a randomized clinical trial.Translational psychiatry · 2025Trial
- Motivational orientation and influencing factors of older adults with chronic obstructive pulmonary disease in community dwellings: a latent profile analysis.BMC geriatrics · 2026Article
- Social approach-avoidance conflict: Behavioural, emotional, and neural correlates along a depression-social anxiety spectrum.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- 6-Shogaol, a neuro-nutraceutical derived from ginger, alleviates motor symptoms and depression-like behaviors and modulates the release of monoamine neurotransmitters in Parkinson's disease mice.European journal of nutrition · 2025Article
- Hippocampal damage disrupts the latent decision-making processes underlying approach-avoidance conflict processing in humans.PLoS biology · 2025Article
- Neural circuit basis of pathological anxiety.Nature reviews. Neuroscience · 2025Review
- The Limbic System in Co-Occurring Substance Use and Anxiety Disorders: A Narrative Review Using the RDoC Framework.Brain sciences · 2024Review
- How Distributed Subcortical Integration of Reward and Threat May Inform Subsequent Approach-Avoidance Decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Quantifying aberrant approach-avoidance conflict in psychopathology: A review of computational approaches.Neuroscience and biobehavioral reviews · 2023Review
- Elevated decision uncertainty and reduced avoidance drives in depression, anxiety and substance use disorders during approach-avoidance conflict: a replication study.Journal of psychiatry & neuroscience : JPNArticle
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Authors and funding
14 authors at 7 institutions in 1 country.
Timothy J McDermottFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle) tmcdermott@laureateinstitute.org.
Hannah BergFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
James TouthangFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
Elisabeth AkemanFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
Mallory J CannonFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
Jessica SantiagoFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
Kelly T CosgroveFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
Ashley N ClausenFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
Namik KirlicFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
Ryan SmithFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
Michelle G CraskeFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
James L AbelsonFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
Martin P PaulusFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
Robin L AupperleFrom the Laureate Institute for Brain Research, Tulsa, OK (McDermott, Berg, Touthang, Akeman, Cannon, Santiago, Cosgrove, Clausen, Kirlic, Smith, Paulus, Aupperle); the Department of Psychology, University of Tulsa, Tulsa, OK (McDermott, Cosgrove); the Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN (Berg); the Department of Psychology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (Craske); the Department of Psychiatry, University of Michigan, Ann Arbor, MI (Abelson); the Department of Community Medicine, University of Tulsa, Tulsa, OK (Paulus, Aupperle).
University of California, Los Angeles · USTwin Cities Orthopedics · USLaureate Institute for Brain Research · USUniversity of Tulsa · USTulsa Community College · USUniversity of Michigan–Ann Arbor · USUniversity of Minnesota · US
Funding
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7MThe Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Wesley Kurt Thompson · 2017 to 2026
$23.7M15/21 ABCD-USA Consortium: Research Project Site at LIBRU01DA050989 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI ROBIN L AUPPERLE, MARTIN P. PAULUS · 2020 to 2026
$14.7MGlucocorticoid modulation of contextual processing and its neurocircuitry: Testing a new model of PTSD pathophysiologyR01MH113574 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABELSON, JAMES L, LIBERZON, ISRAEL · 2018 to 2022
$3.3MAn Approach-Avoidance, Computational Framework for Predicting Behavioral Therapy Outcome in Anxiety and DepressionR01MH123691 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI AUPPERLE, ROBIN L · 2020 to 2024
$2.6MReward Sensitivity as a Mechanism of Positive Affect Treatment for AnhedoniaR33MH115138 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRASKE, MICHELLE G, MEURET, ALICIA ESPERANZA · 2021 to 2023
$2.4MTargeting negative affect through mindfulness training in youth at risk for internalizing problemsR61MH119270 · NIMH · VANDERBILT UNIVERSITY · PI ADAM, EMMA K, CHAVIRA, DENISE A · 2020 to 2021
$1.8MApproach-Avoidance Conflict-a multi-level predictor for exposure therapy responseK23MH108707 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI AUPPERLE, ROBIN L · 2016 to 2020
$976kTreating Phobia with Multivoxel Neuro-reinforcementR61MH113772 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRASKE, MICHELLE G · 2018 to 2019
$932kSelf-regulation of Prefrontal Cortex during Emotional Cognitive ControlF31MH122090 · NIMH · UNIVERSITY OF TULSA · PI MCDERMOTT, TIMOTHY · 2020 to 2022
$102kThe Role of Social and Neural Connectedness in Predicting Neurodevelopmental Functioning in AdolescenceF31HD103340 · NICHD · UNIVERSITY OF TULSA · PI COSGROVE, KELLY THERESA · 2020 to 2021
$90kNICHD NIH HHS F31 HD103340NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA050989NIGMS NIH HHS P20 GM121312NIMH NIH HHS F31 MH122090NIMH NIH HHS K23 MH108707NIMH NIH HHS R01 MH113574NIMH NIH HHS R01 MH123691NIMH NIH HHS R33 MH115138NIMH NIH HHS R61 MH113772NIMH NIH HHS R61 MH119270
Abstract
backgroundWe have previously reported activation in reward, salience and executive control regions during functional MRI (fMRI) using an approach-avoidance conflict (AAC) decision-making task with healthy adults. Further investigations into how anxiety and depressive disorders relate to differences in neural responses during AAC can inform their understanding and treatment. We tested the hypothesis that people with anxiety or depression have altered neural activation during AAC.
methodsWe compared 118 treatment-seeking adults with anxiety or depression and 58 healthy adults using linear mixed-effects models to examine group-level differences in neural activation (fMRI) during AAC decision-making. Correlational analyses examined relationships between behavioural and neural measures.
resultsAdults with anxiety or depression had greater striatal engagement when reacting to affective stimuli ( LIMITATIONS: Our transdiagnostic approach did not allow for comparisons between specific anxiety disorders, and our cross-sectional approach did not allow for causal inference.
conclusionAnxiety and depression were associated with altered neural responses to AAC. Findings were consistent with the role of the striatum in action selection and reward responsivity, and they point toward striatal reactivity as a future treatment target. Blunting of amygdala activity in anxiety or depression may indicate a compensatory response to inhibit affective salience and maintain approach.
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DepressionRewardAdultAnxietyAnxiety DisordersCorpus StriatumHumansMagnetic Resonance Imaging
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