Evidence map›Paper›PMID 36222971›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2022

Differential cholinergic systems' changes in progressive supranuclear palsy versus Parkinson's disease: an exploratory analysis.

Prabesh Kanel, C Chauncey Spears, Stiven Roytman, Robert A Koeppe, Kirk A Frey, Peter J H Scott, Roger L Albin, Nicolaas I Bohnen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  4. Review
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  7. A novelFrontiers in neurology · 2024
    Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Prabesh KanelDepartment of Radiology, University of Michigan, MI, Ann Arbor, USA. prabeshk@umich.edu.ORCID 0000-0003-1418-2960
C Chauncey SpearsDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Stiven RoytmanDepartment of Radiology, University of Michigan, MI, Ann Arbor, USA.
Robert A KoeppeDepartment of Radiology, University of Michigan, MI, Ann Arbor, USA.
Kirk A FreyDepartment of Radiology, University of Michigan, MI, Ann Arbor, USA.
Peter J H ScottDepartment of Radiology, University of Michigan, MI, Ann Arbor, USA.
Roger L AlbinMorris K. Udall Center of Excellence for Parkinson's Disease Research, University of Michigan, Ann Arbor, MI, USA.
Nicolaas I BohnenDepartment of Radiology, University of Michigan, MI, Ann Arbor, USA.
University of Michigan · US

Funding

Tomography and Data AnalysisP01NS015655 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOEPPE, ROBERT A · 1985 to 2012
$13.0M
Udall Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration DysfunctionP50NS123067 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AHMED, OMAR JAMIL · 2021 to 2025
$11.6M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2019
$10.1M
Hyposmia, Cholinergic Denervation and Incipient Cognitive Decline in PDR01NS070856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2010 to 2014
$1.9M
Amyloidopathy, cholinopathy, dopamine responsiveness and freezing of gait in PDI01RX001631 · VA · VETERANS HEALTH ADMINISTRATION · PI BOHNEN, NICOLAAS IDA · 2016 to 2020
–
NIH HHS RO1 NS070856NINDS NIH HHS P01 NS015655NINDS NIH HHS P50 NS091856NINDS NIH HHS P50 NS123067NINDS NIH HHS R01 NS070856RRD VA I01 RX001631
6 · The paper itself

Abstract

Prior studies indicate more severe brainstem cholinergic deficits in Progressive Supranuclear Palsy (PSP) compared to Parkinson's disease (PD), but the extent and topography of subcortical deficits remains poorly understood. The objective of this study is to investigate differential cholinergic systems changes in progressive supranuclear palsy (PSP, n = 8) versus Parkinson's disease (PD, n = 107) and older controls (n = 19) using vesicular acetylcholine transporter [

Indexed as

Parkinson DiseasePedunculopontine Tegmental NucleusSupranuclear Palsy, ProgressiveCholinergic AgentsHumansPositron-Emission TomographyCholinergic AgentsAcetylcholineCerebellumMedial geniculate nucleusMotor impairmentsParkinson's disease

Identifiers

PMID36222971
PMCPMC10017092
OpenAlexW4304690834

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.