Evidence map›Paper›PMID 36222962›Full record

ArticleJournal of molecular modeling2022

Reactivity and binding mode of disulfiram, its metabolites, and derivatives in SARS-CoV-2 PL

Pablo Andrei Nogara, Folorunsho Bright Omage, Gustavo Roni Bolzan, Cássia Pereira Delgado, Laura Orian, João Batista Teixeira Rocha

Open access · bronzeAbstract read
In one paragraph

Article in Journal of molecular modeling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Pablo Andrei NogaraDepartamento de Bioquímica E Biologia Molecular, Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS, 97105-900, Brazil. pbnogara@gmail.com.ORCID http://orcid.org/0000-0002-9133-6102
Folorunsho Bright OmageDepartamento de Bioquímica E Biologia Molecular, Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS, 97105-900, Brazil.
Gustavo Roni BolzanDepartamento de Bioquímica E Biologia Molecular, Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS, 97105-900, Brazil.
Cássia Pereira DelgadoDepartamento de Bioquímica E Biologia Molecular, Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS, 97105-900, Brazil.
Laura OrianDipartimento Di Scienze Chimiche, Università Degli Studi Di Padova, Via Marzolo 1, 35131, Padua, Italy.ORCID http://orcid.org/0000-0002-1673-5111
João Batista Teixeira RochaDepartamento de Bioquímica E Biologia Molecular, Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS, 97105-900, Brazil. jbtrocha@yahoo.com.br.ORCID http://orcid.org/0000-0003-3829-0595
Universidade Federal de Santa Maria · BRUniversity of Padua · IT

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 09-88887.505377/2020-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 23038.005848/2018-31Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.354370/2019-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.511828/2020-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.512045/2020-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.512885/2020-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior BIRD2018-UNIPD
6 · The paper itself

Abstract

The papain-like protease (PL

Indexed as

COVID-19 Drug TreatmentSARS-CoV-2Antiviral AgentsClinical Trials as TopicComputational ChemistryCysteineDisulfiramHumansMolecular Docking SimulationPapainPeptide HydrolasesProtease InhibitorsSulfoxidesAntiviral AgentsCysteineDisulfiramPapainPeptide HydrolasesProtease InhibitorsSulfoxidesAntiviral compoundsCOVID-19DFT calculationsDisulfiramDockingOrganochalcogens

Identifiers

PMID36222962
PMCPMC9554863
OpenAlexW4304689617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.