Evidence map›Paper›PMID 36222651›Full record

ArticleeLife2022

The Na

Dylan J Meyer, Carlos Manlio Díaz-García, Nidhi Nathwani, Mahia Rahman, Gary Yellen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Steroid hormone ouabain cooperates with NaActa pharmaceutica Sinica. B · 2026
    Article
  3. Review
  4. Article
  5. Inorganic phosphate and the rapid mobilization of metabolic energy in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Glycolytic Specialization Shapes Neuronal Physiology and FunctionbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Review
  10. Glycolytic activation of β-cell NaMolecular metabolism · 2026
    Article
  11. Direct energy consumption by inhibitory GABAFrontiers in neuroscience · 2026
    Article
  12. Article
  13. Article
  14. Glycogen supports glycolytic plasticity in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Review
  16. Review
  17. Review
  18. Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Review
  20. Disrupting NaCancer & metabolism · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dylan J MeyerDepartment of Neurobiology, Harvard Medical School, Boston, United States.ORCID 0000-0001-8453-3813
Carlos Manlio Díaz-GarcíaDepartment of Neurobiology, Harvard Medical School, Boston, United States.ORCID 0000-0002-4352-2496
Nidhi NathwaniDepartment of Neurobiology, Harvard Medical School, Boston, United States.
Mahia RahmanDepartment of Neurobiology, Harvard Medical School, Boston, United States.
Gary YellenDepartment of Neurobiology, Harvard Medical School, Boston, United States.ORCID 0000-0003-4228-7866
Harvard University · US

Funding

High-throughput optimization of genetically-encoded fluorescent biosensorsR01GM124038 · NIGMS · HARVARD MEDICAL SCHOOL · PI YELLEN, GARY I · 2017 to 2025
$2.5M
Mechanisms of seizure resistance in a mouse genetic model with altered metabolismR01NS102586 · NINDS · HARVARD MEDICAL SCHOOL · PI YELLEN, GARY I · 2018 to 2022
$1.9M
Defining the cellular metabolic responses to brain activity using fluorescent biosensorsF32NS100331 · NINDS · HARVARD MEDICAL SCHOOL · PI DIAZ GARCIA, CARLOS MANLIO · 2017 to 2019
$190k
Metabolic coupling of neuronal ion transportF32NS116105 · NINDS · HARVARD MEDICAL SCHOOL · PI MEYER, DYLAN JOHN · 2020 to 2022
$147k
NIGMS NIH HHS R01 GM124038NINDS NIH HHS F32 NS100331NINDS NIH HHS F32 NS116105NINDS NIH HHS R01 NS102586
6 · The paper itself

Abstract

Cellular ATP that is consumed to perform energetically expensive tasks must be replenished by new ATP through the activation of metabolism. Neuronal stimulation, an energetically demanding process, transiently activates aerobic glycolysis, but the precise mechanism underlying this glycolysis activation has not been determined. We previously showed that neuronal glycolysis is correlated with Ca

Indexed as

CalciumNADAdenosine TriphosphateAnimalsColoring AgentsGlycolysisHippocampusMiceSodiumSodium-Calcium ExchangerAdenosine TriphosphateCalciumColoring AgentsNADSodiumSodium-Calcium Exchangercell biologycytosolic NADHglycolysismouseNa-Ca exchangeNa-K pumpneuronsneuroscience

Identifiers

PMID36222651
PMCPMC9592084
OpenAlexW4304692485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.