Evidence map›Paper›PMID 36222627›Full record

ArticleJournal of psychopathology and clinical science2022

Assessing general versus specific liability for externalizing problems in adolescence: Concurrent and prospective prediction of symptoms of conduct disorder, ADHD, and substance use.

Emily R Perkins, Keanan J Joyner, Jens Foell, Laura E Drislane, Sarah J Brislin, Paul J Frick, James R Yancey, Elia F Soto, Colleen M Ganley, Pamela K Keel and 24 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of psychopathology and clinical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 18 institutions in 9 countries.

Emily R PerkinsDepartment of Psychology, Florida State University.ORCID 0000-0003-3473-8962
Keanan J JoynerDepartment of Psychology, Florida State University.
Jens FoellDepartment of Psychology, Florida State University.ORCID 0000-0002-2089-094X
Laura E DrislaneDepartment of Psychology, Sam Houston State University.ORCID 0000-0002-5816-9074
Sarah J BrislinDepartment of Psychology, Virginia Commonwealth University.ORCID 0000-0003-4303-8124
Paul J FrickDepartment of Psychology, Louisiana State University.
James R YanceyRocky Mountain Network Mental Illness Research, Education, and Clinical Center, VA Salt Lake City Health Care System.
Elia F SotoDepartment of Psychology, Florida State University.ORCID 0000-0002-6672-287X
Colleen M GanleyDepartment of Psychology, Florida State University.ORCID 0000-0002-8902-9189
Pamela K KeelDepartment of Psychology, Florida State University.ORCID 0000-0001-6542-5147
Claudio SicaDepartment of Health Sciences, University of Firenze.ORCID 0000-0002-2189-8601
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University.
Frauke NeesDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University.ORCID 0000-0002-7796-8234
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University.ORCID 0000-0003-4595-1144
Arun L W BokdeDiscipline of Psychiatry, Trinity College Dublin.ORCID 0000-0003-0114-4914
Sylvane DesrivièresInstitute of Psychiatry, Psychology and Neuroscience, King's College London.
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay.
Hugh GaravanDepartment of Psychiatry, University of Vermont.
Penny GowlandSir Peter Mansfeld Imaging Centre, School of Physics and Astronomy, University of Nottingham - University Park.ORCID 0000-0002-4900-4817
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin.
Bernd IttermannDepartment of Biomedical Magnetic Resonance, Physikalisch-Technische Bundesanstalt.ORCID 0000-0002-4087-471X
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales en psychiatrie".ORCID 0000-0002-0136-0388
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales en psychiatrie".ORCID 0000-0002-0452-2450
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales en psychiatrie".ORCID 0000-0003-4461-7646
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay.ORCID 0000-0002-1242-8990
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University.ORCID 0000-0002-5175-6698
Juliane H FröhnerDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden.ORCID 0000-0002-8493-6396
Michael N SmolkaDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden.ORCID 0000-0001-5398-5569
Henrik WalterDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin.
Robert WhelanTrinity College Institute of Neuroscience, Trinity College Dublin.ORCID 0000-0002-2790-7281
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University.
The Imagen Consortium
Christopher J PatrickDepartment of Psychology, Florida State University.
Florida State University · USCentre National de la Recherche Scientifique · FRHeidelberg University · DECharité - Universitätsmedizin Berlin · DECommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRKing's College London · GBTechnische Universität Dresden · DELouisiana State University · USPhysikalisch-Technische Bundesanstalt · DESam Houston State University · USTrinity College · CATrinity College Dublin · IEUniversity of Florence · ITUniversity of Mannheim · DEUniversity of Nottingham · GBUniversity of Utah · USUniversity of Vermont · USVirginia Commonwealth University · US

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
MULTIDISCIPLINARY ALCOHOLISM RESEARCH TRAINING PROGRAMT32AA007477 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maureen A. Walton · 1990 to 2026
$7.4M
A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9M
Integrated Clinical Neuroscience Training for Translational ResearchT32MH093311 · NIMH · FLORIDA STATE UNIVERSITY · PI LISA A ECKEL, Pamela K. Keel · 2012 to 2026
$2.3M
Axon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5M
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
Callousness and Distress Processing: An ERP Investigation of Attention and Emotion in Adolescence.F31MH122096 · NIMH · FLORIDA STATE UNIVERSITY · PI PERKINS, EMILY REED · 2019 to 2020
$74k
Agence Nationale de la RechercheAssistance-Publique-Hôpitaux-de-ParisBundesministeriumf€ur Bildung und Forschung (BMBF)Deutsche ForschungsgemeinschaftEuropean Research Area Network on Illicit DrugsEuropean Research Council 695313European UnionFédération pour la Recherche sur le CerveauFondation de FranceFondation de l'AvenirFondation pour la Recherche MedicaleHuman Brain ProjectInstitut National de la Santé et de la Recherche Médicale (INSERM)King's College LondonMaudsley National Health Service Foundation TrustMedical Research Council MR/N000390/1Medical Research Council MR/R00465X/1Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-AddictivesMRFNational Institute for Health Research; Policy Research ProgrammeNIAAA NIH HHS T32 AA007477NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA049238NIHR Biomedical Research Center at South LondonNIMH NIH HHS F31 MH122096NIMH NIH HHS R01 MH085772NIMH NIH HHS T32 MH093311Paris Sud UniversityScience Foundation IrelandU.S. Army
6 · The paper itself

Abstract

This study explored the generality versus specificity of two trait-liability factors for externalizing problems-disinhibition and callousness-in the concurrent and prospective prediction of symptoms of conduct disorder, attention-deficit/hyperactivity disorder (ADHD), and substance use (i.e., alcohol use disorder and history of illicit substance use). Disinhibition involves an impulsive, unrestrained cognitive-behavioral style; callousness entails a dispositional lack of social-emotional sensitivity. Participants were European adolescents from the multisite IMAGEN project who completed questionnaires and clinical interviews at ages 14 (N = 1,504, Mage = 14.41, 51.13% female) and 16 (N = 1,407, Mage = 16.46, 51.88% female). Disinhibition was related concurrently and prospectively to greater symptoms of conduct disorder, ADHD, and alcohol use disorder; higher scores on a general externalizing factor; and greater likelihood of having tried an illicit substance. Callousness was selectively related to greater conduct disorder symptoms. These findings indicate disinhibition confers broad liability for externalizing spectrum disorders, perhaps due to its affiliated deficits in executive function. In contrast, callousness appears to represent more specific liability for antagonistic (aggressive/exploitative) forms of externalizing, as exemplified by antisocial behavior. Results support the utility of developmental-ontogenetic and hierarchical-dimensional models of psychopathology and have important implications for early assessment of risk for externalizing problems. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Indexed as

AlcoholismAttention Deficit Disorder with HyperactivityConduct DisorderSubstance-Related DisordersAdolescentFemaleHumansMaleProspective Studies

Identifiers

PMID36222627
PMCPMC9710196
OpenAlexW4304587499

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.