ArticleThe Plant cell2023
The Phytophthora sojae nuclear effector PsAvh110 targets a host transcriptional complex to modulate plant immunity.
Article in The Plant cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Late Blight Effector Pi05910 Suppresses Plant Immunity by Promoting Destabilisation of Host Scaffold Protein RACK1.Molecular plant pathology · 2026Article
- Effector-Mediated Spatial Reprogramming of Glycolate Oxidase Subverts Peroxisomal and Membrane-Associated ROS Defences.Plant biotechnology journal · 2026Article
- An Ustilaginoidea virens Nuclear Effector SCRE7 Inhibits Rice Immunity via Suppressing OsLBD11/12-Promoted Transcription of OsCPS2.Plant biotechnology journal · 2026Article
- Alternaria alternata Effector Aa593 Promotes Virulence by Hijacking the CmNAC29-Mediated Abscisic Acid Biosynthesis Pathway in Chrysanthemum.Plant biotechnology journal · 2026Article
- A GmNRF5a-GmCERK1-GmCAK1 module mediates chitin/chitosan-triggered immune response in soybean.Journal of integrative plant biology · 2026Article
- Article
- A chromatin-linked CPL2-PHD2/3 module sustains multiple DNA methylation pathways and Polycomb silencing.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- GmERF1 positively regulates soybean resistance to Phytophthora sojae by enhancing salicylic acid signaling.Plant cell reports · 2025Article
- A Novel Effector FoUpe9 Enhances the Virulence ofJournal of fungi (Basel, Switzerland) · 2025Article
- The Three-Dimensional Structure of the Genome of the Dark Septate EndophyteJournal of fungi (Basel, Switzerland) · 2025Article
- Plant PR1 rescues condensation of the plastid iron-sulfur protein by a fungal effector.Nature plants · 2024Article
- Article
- Mitogen-activated protein kinases MPK3 and MPK6 phosphorylate receptor-like cytoplasmic kinase CDL1 to regulate soybean basal immunity.The Plant cell · 2024Article
- Genome-Wide Identification and Characterization of Effector Candidates with Conserved Motif inInternational journal of molecular sciences · 2024Article
- Mechanisms of rhizosphere plant-microbe interactions: molecular insights into microbial colonization.Frontiers in plant science · 2024Review
- Recent advances in nano-enabled immunomodulation for enhancing plant resilience against phytopathogens.Frontiers in plant science · 2024Review
- Stripe Rust Effector Pst_9302 Inhibits Wheat Immunity to Promote Susceptibility.Plants (Basel, Switzerland) · 2023Article
- Rice stripe virus nonstructural protein 3 suppresses plant defence responses mediated by the MEL-SHMT1 module.Molecular plant pathology · 2023Article
- A nonclassically secreted effector of Magnaporthe oryzae targets host nuclei and plays important roles in fungal growth and plant infection.Molecular plant pathology · 2023Article
- The effectors of Phytophthora infestans impact host immunity upon regulation of antagonistic hormonal activities.Planta · 2023Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants have evolved sophisticated immune networks to restrict pathogen colonization. In response, pathogens deploy numerous virulent effectors to circumvent plant immune responses. However, the molecular mechanisms by which pathogen-derived effectors suppress plant defenses remain elusive. Here, we report that the nucleus-localized RxLR effector PsAvh110 from the pathogen Phytophthora sojae, causing soybean (Glycine max) stem and root rot, modulates the activity of a transcriptional complex to suppress plant immunity. Soybean like-heterochromatin protein 1-2 (GmLHP1-2) and plant homeodomain finger protein 6 (GmPHD6) form a transcriptional complex with transcriptional activity that positively regulates plant immunity against Phytophthora infection. To suppress plant immunity, the nuclear effector PsAvh110 disrupts the assembly of the GmLHP1-2/GmPHD6 complex via specifically binding to GmLHP1-2, thus blocking its transcriptional activity. We further show that PsAvh110 represses the expression of a subset of immune-associated genes, including BRI1-associated receptor kinase 1-3 (GmBAK1-3) and pathogenesis-related protein 1 (GmPR1), via G-rich elements in gene promoters. Importantly, PsAvh110 is a conserved effector in different Phytophthora species, suggesting that the PsAvh110 regulatory mechanism might be widely utilized in the genus to manipulate plant immunity. Thus, our study reveals a regulatory mechanism by which pathogen effectors target a transcriptional complex to reprogram transcription.
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