Evidence map›Paper›PMID 36222510›Full record

ArticlemBio2022

Macrophage Mitochondrial Biogenesis and Metabolic Reprogramming Induced by Leishmania donovani Require Lipophosphoglycan and Type I Interferon Signaling.

Hamlet Acevedo Ospina, Marie-Michèle Guay-Vincent, Albert Descoteaux

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Frontiers in immunology · 2026
    Review
  5. Review
  6. Interaction BetweenMicroorganisms · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hamlet Acevedo OspinaINRS-Centre Armand-Frappier Santé Biotechnologie, Laval, Quebec, Canada.
Marie-Michèle Guay-VincentINRS-Centre Armand-Frappier Santé Biotechnologie, Laval, Quebec, Canada.
Albert DescoteauxINRS-Centre Armand-Frappier Santé Biotechnologie, Laval, Quebec, Canada.ORCID 0000-0002-0633-5309
Institut National de la Recherche Scientifique · CA

Funding

CIHR PJT-156416
6 · The paper itself

Abstract

Pathogen-specific rewiring of host cell metabolism creates the metabolically adapted microenvironment required for pathogen replication. Here, we investigated the mechanisms governing the modulation of macrophage mitochondrial properties by the vacuolar pathogen

Indexed as

Leishmania donovaniGlycosphingolipidsMacrophagesOrganelle BiogenesisGlycosphingolipidslipophosphonoglycanIFNARLeishmanialipophosphoglycanmacrophagesmitochondria

Identifiers

PMID36222510
PMCPMC9764995
OpenAlexW4304693653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.