Evidence map›Paper›PMID 36222425›Full record

ArticleThe journal of physical chemistry. B2022

Molecular Insights into the Binding of Linear Polyethylenimines and Single-Stranded DNA Using Raman Spectroscopy: A Quantitative Approach.

Rusul Mustafa, Maria Fitian, Nicholas B Hamilton, Jianing Li, W Ruchira Silva, David Punihaole

Abstract read
In one paragraph

Article in The journal of physical chemistry. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Low-frequency Raman spectra of amyloid fibrils.The Journal of chemical physics · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rusul MustafaDepartment of Chemistry, University of Vermont, Burlington, Vermont05405, United States.
Maria FitianDepartment of Chemistry and Biochemistry, Siena College, Loudonville, New York12211, United States.
Nicholas B HamiltonDepartment of Chemistry, University of Vermont, Burlington, Vermont05405, United States.
Jianing LiDepartment of Chemistry, University of Vermont, Burlington, Vermont05405, United States.ORCID 0000-0002-0143-8894
W Ruchira SilvaDepartment of Chemistry and Biochemistry, Siena College, Loudonville, New York12211, United States.ORCID 0000-0003-3769-6681
David PunihaoleDepartment of Chemistry, University of Vermont, Burlington, Vermont05405, United States.ORCID 0000-0002-4637-9672

Funding

Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kathryn H Morelli · 2020 to 2026
$17.4M
Strategic inhibition of EGFR-family signaling using novel peptidomimetic inhibitors of HER-2 for the treatment of osteosarcomaP20GM135000 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI CHAMCHEU, JEAN CHRISTOPHER · 2021 to 2025
$11.3M
Structure, Mechanism, and Regulation of PACAP/VIP GPCR SubtypesR01GM129431 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LI, JIANING · 2018 to 2022
$1.7M
NIGMS NIH HHS P20 GM135000NIGMS NIH HHS P20 GM135007NIGMS NIH HHS R01 GM129431
6 · The paper itself

Abstract

Establishing how polymeric vectors such as polyethylenimine (PEI) bind and package their nucleic acid cargo is vital toward developing more efficacious and cost-effective gene therapies. To develop a molecular-level picture of DNA binding, we examined how the Raman spectra of PEIs report on their local chemical environment. We find that the intense Raman bands located in the 1400-1500 cm

Indexed as

PolyethyleneimineSpectrum Analysis, RamanAminesDNA, Single-StrandedPhosphatesAminesDNA, Single-StrandedPhosphatesPolyethyleneimine

Identifiers

PMID36222425
PMCPMC10413332

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.