Evidence map›Paper›PMID 36222279›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2023

Highly Cytotoxic Molybdenocenes with Strong Metabolic Effects Inhibit Tumour Growth in Mice.

Valentin Fuchs, Klaudia Cseh, Michaela Hejl, Petra Vician, Benjamin Neuditschko, Samuel M Meier-Menches, Lukas Janker, Andrea Bileck, Natalie Gajic, Julia Kronberger and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Valentin FuchsInstitute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0001-5721-4219
Klaudia CsehInstitute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0001-7511-5206
Michaela HejlInstitute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria.
Petra VicianCenter for Cancer Research, Medical University of Vienna, Borschkegasse 8 A, 1090, Vienna, Austria.
Benjamin NeuditschkoInstitute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0002-7024-7493
Samuel M Meier-MenchesInstitute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0002-8930-4574
Lukas JankerInstitute of Analytical Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0002-3084-2212
Andrea BileckInstitute of Analytical Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0002-7053-8856
Natalie GajicInstitute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0002-6787-6686
Julia KronbergerInstitute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria.
Martin SchaierInstitute of Analytical Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0003-4907-218X
Sophie NeumayerInstitute of Analytical Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria.
Gunda KöllenspergerInstitute of Analytical Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria.
Christopher GernerInstitute of Analytical Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0003-4964-0642
Walter BergerCenter for Cancer Research, Medical University of Vienna, Borschkegasse 8 A, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0003-0014-1658
Michael A JakupecInstitute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0001-7945-1426
Michael S MalarekInstitute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0002-0332-7776
Bernhard K KepplerInstitute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0003-0877-1822
University of Vienna · ATComprehensive Cancer Center Vienna · AT

Funding

Medizinische Universität WienUniversität Wien
6 · The paper itself

Abstract

A series of six highly lipophilic Cp-substituted molybdenocenes bearing different bioactive chelating ligands was synthesized and characterized by NMR spectroscopy, mass spectrometry and X-ray crystallography. In vitro experiments showed a greatly increased cytotoxic potency when compared to the non-Cp-substituted counterparts. In vivo experiments performed with the dichlorido precursor, (Ph

Indexed as

Antineoplastic AgentsNeoplasmsAnimalsCell Line, TumorChelating AgentsCrystallography, X-RayLigandsMiceMolecular StructureProteomicsAntineoplastic AgentsChelating AgentsLigandsanticancerbiological tests (in vitro and in vivo)bioorganometallic chemistrymolybdenocenesproteomics

Identifiers

PMID36222279
PMCPMC10099754
OpenAlexW4304689497

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.