ArticleActa obstetricia et gynecologica Scandinavica2023
The association of smoking, use of snuff, and preconception alcohol consumption with spontaneous abortion: A population-based cohort study.
Article in Acta obstetricia et gynecologica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Mendelian randomization reveals the associations between modifiable risk factors and intermediate phenotypes and spontaneous abortion.BMC pregnancy and childbirth · 2026Article
- Knowledge and engagement in health-promoting behaviors among women planning pregnancy: a cross-sectional study.BMC women's health · 2026Article
- Age among women and men, time to pregnancy and risk of miscarriage.BMC medicine · 2025Article
- Substance use and use disorders during pregnancy and the postpartum period.American journal of obstetrics and gynecology · 2025Review
- Tobacco exposure and risk of spontaneous abortion, a dose-dependent association: A systematic review and meta-analysis.Tobacco induced diseases · 2025Article
- A Systematic Review of Mendelian Randomization in Spontaneous Miscarriage.Journal of multidisciplinary healthcare · 2025Review
- Article
- The association of smoking, use of snuff, and preconception alcohol consumption with spontaneous abortion: A population-based cohort study.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Associations between obesity, smoking behaviors, reproductive traits and spontaneous abortion: a univariable and multivariable Mendelian randomization study.Frontiers in endocrinology · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
introductionIt is unclear whether tobacco in early pregnancy and alcohol use preceding pregnancy are associated with spontaneous abortion. The purpose was to investigate if use of tobacco and/or alcohol is associated with spontaneous abortion among women attending antenatal care, and if age and body mass index (BMI) attenuate the risk. MATERIAL AND
methodsA population-based cohort study based on data from the Swedish Pregnancy Register. All pregnant women having had the first antenatal visit from January 2014 to July 2018 were included (n = 525 604). The register had information about smoking and use of snuff before and in early pregnancy, as well as data on alcohol habits before pregnancy, measured by the Alcohol Use Disorders Identification Test (AUDIT), a validated questionnaire. Logistic regression analysis was used to estimate the association between lifestyle factors and spontaneous abortion, and multiple imputation was used to impute missing data.
resultsIn total, 34 867 (6.6%) pregnancies ended in a spontaneous abortion after the first visit to maternal health care. At the first maternal healthcare visit, daily smoking was reported by 24 214 (5.1%), and 6403 (1.2%) used snuff. For 19 837 (4.2%) women, a high alcohol score was reported for the year preceding pregnancy. After adjusting for potential confounders and multiple imputation, use of tobacco was associated with spontaneous abortion; smoking 1-9 cigarettes/day (adjusted odds ratio [aOR] 1.11, 95% confidence interval [CI] 1.04-1.18), smoking 10 or more cigarettes/day (aOR 1.12, 95% CI 1.-1.26), and use of snuff (aOR 1.20, 95% CI 1.06-1.37). Higher AUDIT scores were not significantly associated with spontaneous abortion (AUDIT 6-9: aOR 1.03, 95% CI 0.97-1.10 and AUDIT 10 or more: aOR 1.07, 95% CI 0.94-1.22). Increasing maternal age showed the highest risk of spontaneous abortion from the age of 35, and BMI of 30 kg/m
conclusionsSmoking and use of snuff were associated with an increased risk of spontaneous abortion. The AUDIT scores preceding pregnancy were not associated with an increased risk of spontaneous abortion, which contradicts the results from previous studies.
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