ReviewJournal of biosciences2022
Discovering design principles for biological functionalities:Perspectives from systems biology.
Review in Journal of biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- An emerging role for tissue plasticity in developmental precision.Biochemical Society transactions · 2024Review
- Editorial: Secondary metabolism: an unlimited foundation for synthetic biology, volume II.Frontiers in microbiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Network architecture plays a crucial role in governing the dynamics of any biological network. Further, network structures have been shown to remain conserved across organisms for a given phenotype. Therefore, the mapping between network structures and the output functionality not only aids in understanding of biological systems but also finds application in synthetic biology and therapeutics. Based on the approaches involved, most of the efforts hitherto invested in this field can be classified into three broad categories, namely, computational efforts, rule-based methods and systems-theoretic approaches. The present review provides a qualitative and quantitative study of all three approaches in the light of three well-researched biological phenotypes, namely, oscillation, toggle switching, and adaptation. We also discuss the advantages, limitations, and future research scope for all three approaches along with their possible applications to other emergent properties of biological relevance.
Indexed as
Identifiers
36222149What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.