ReviewJournal of biosciences2022
Role of microRNAs in regulation of insulin secretion and insulin signaling involved in type 2 diabetes mellitus.
Review in Journal of biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- The Significance of miRNA-375 in β-cell Function and Autoimmune Destruction in Type 1 Diabetes Mellitus: A Review Article.Reviews on recent clinical trials · 2026Article
- Swimming exercise improves vascular function and mitigates cardiac apoptotic response via Bcl-2 and Caspase-3 pathway in streptozotocin-induced diabetic rats: in vivo and in silico molecular docking study.European journal of medical research · 2025Article
- Exploring the Evidence for Personalized Pharmacotherapy in Type 2 Diabetes-A Systematic Review.Journal of personalized medicine · 2025Review
- Involvement of miRNAs in the Cluster of Metabolic Factors of MetS: Nutrition-Genome-MetS Axis.Journal of clinical medicine · 2025Review
- Identification and Functional Analysis of Key microRNAs in the Early Extrauterine Environmental Adaptation of Piglets.International journal of molecular sciences · 2025Article
- The role of miR-143/miR-145 in the development, diagnosis, and treatment of diabetes.Journal of diabetes and metabolic disorders · 2024Review
- Peeling the onion: another layer in the regulation of insulin secretion.The Journal of clinical investigation · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder due to insulin resistance that can be caused by both genetic and environmental factors. In 2018, the American Diabetes Association (ADA) estimated more than 500 million T2DM cases globally. In recent years, studies conducted on humans and animals have suggested that non-coding RNAs, namely, microRNAs (miRNAs), post-transcriptionally regulate gene expression that can bring changes in normal physiology, resulting in the development of metabolic diseases. miRNAs also regulate different cellular processes including insulin synthesis and its secretion from pancreatic β-islet cells, its development and function, insulin signaling and glucose homeostasis. Dysregulation of miRNA can affect the functioning of different tissues during the progression of T2DM. This review focuses on various miRNAs that influence the development of β-cells and insulin secretion, various protein cascades that play an important role in insulin signaling and glucose uptake, and their role in insulin resistance. Similarly, the long noncoding RNAs also known as lncRNAs and their β-cell characteristics involved in T2DM have been discussed. Finally, the significance of miRNAs and their mRNA targets as effective biomarkers and therapeutics in studying the early onset and progression of T2DM have been highlighted.
Indexed as
Identifiers
36222140W4295989481What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.