Evidence map›Paper›PMID 36222101›Full record

ArticleThe Analyst2022

Label-free fibre optic Raman spectroscopy with bounded simplex-structured matrix factorization for the serial study of serum in amyotrophic lateral sclerosis.

James J P Alix, Nick S Verber, Chlöe N Schooling, Visakan Kadirkamanathan, Martin R Turner, Andrea Malaspina, John C C Day, Pamela J Shaw

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Analyst, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

James J P AlixSheffield Institute for Translational Neuroscience, University of Sheffield, UK. j.alix@sheffield.ac.uk.ORCID http://orcid.org/0000-0001-8391-9749
Nick S VerberSheffield Institute for Translational Neuroscience, University of Sheffield, UK. j.alix@sheffield.ac.uk.
Chlöe N SchoolingSheffield Institute for Translational Neuroscience, University of Sheffield, UK. j.alix@sheffield.ac.uk.
Visakan KadirkamanathanDepartment of Automatic Control and Systems Engineering, University of Sheffield, UK.
Martin R TurnerNuffield Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Andrea MalaspinaBlizard Institute, Queen Mary University of London, London, UK.
John C C DayInterface Analysis Centre, School of Physics, University of Bristol, UK.
Pamela J ShawSheffield Institute for Translational Neuroscience, University of Sheffield, UK. j.alix@sheffield.ac.uk.
University of Sheffield · GBQueen Mary University of London · GBUniversity of Bristol · GBUniversity of Oxford · GB

Funding

Motor Neurone Disease Association MALASPINA/APR13/817-791Motor Neurone Disease Association TURNER/OCT15/972-797Motor Neurone Disease Association TURNER/OCT18/989-797
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease in urgent need of disease biomarkers for the assessment of promising therapeutic candidates in clinical trials. Raman spectroscopy is an attractive technique for identifying disease related molecular changes due to its simplicity. Here, we describe a fibre optic fluid cell for undertaking spontaneous Raman spectroscopy studies of human biofluids that is suitable for use away from a standard laboratory setting. Using this system, we examined serum obtained from patients with ALS at their first presentation to our centre (

Indexed as

Amyotrophic Lateral SclerosisNeurodegenerative DiseasesBiomarkersC-Reactive ProteinHumansSpectrum Analysis, RamanBiomarkersC-Reactive Protein

Identifiers

PMID36222101
PMCPMC9639415
OpenAlexW4304758069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.