Evidence map›Paper›PMID 36221944›Full record

ArticleJournal of stroke2022

Outcome Prediction in Cerebral Venous Thrombosis: The IN-REvASC Score.

Piers Klein, Liqi Shu, Thanh N Nguyen, James E Siegler, Setareh Salehi Omran, Alexis N Simpkins, Mirjam Heldner, Adam de Havenon, Hugo J Aparicio, Mohamad Abdalkader and 9 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
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  11. Cerebral venous thrombosis: Current management, recent advances and future directions.International journal of stroke : official journal of the International Stroke Society · 2025
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  16. International practice patterns and perspectives on endovascular therapy for the treatment of cerebral venous thrombosis.International journal of stroke : official journal of the International Stroke Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 13 institutions in 5 countries.

Piers KleinDepartment of Neurology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
Liqi ShuDepartment of Neurology, Brown University, Providence, RI, USA.
Thanh N NguyenDepartment of Neurology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
James E SieglerDepartment of Neurology, Cooper Neurological Institute, Cooper University Hospital, Camden, NJ, USA.
Setareh Salehi OmranDepartment of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.
Alexis N SimpkinsDepartment of Neurology, University of Florida, Gainesville, FL, USA.
Mirjam HeldnerDepartment of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
Adam de HavenonDepartment of Neurology, Yale University, New Haven, CT, USA.
Hugo J AparicioDepartment of Neurology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
Mohamad AbdalkaderDepartment of Neurology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
Marios PsychogiosDepartment of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
Maria Cristina VedovatiDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Maurizio PaciaroniNeurology-Stroke Unit, IRCCS MultiMedica, Milano, Italy.
Rascha von MartialDepartment of Neurology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland.
David S LiebeskindDepartment of Neurology, University of California at Los Angeles, Los Angeles, CA, USA.
Diana Aguiar de SousaDepartment of Neurosciences and Mental Health, Neurology Service, Hospital de Santa Maria/CHULN, University of Lisbon, Lisbon, Portugal.
Jonathan M CoutinhoDepartment of Neurology, Amsterdam University Medical Center, location AMC, Amsterdam, The Netherlands.
Shadi YaghiDepartment of Neurology, Brown University, Providence, RI, USA.
ACTION-CVT Study GroupDepartment of Neurology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
Boston University · USBrown University · USUniversity of Bern · CHAmsterdam University Medical Centers · NLCooper University Hospital · USMultiMedica · ITUniversity Hospital of Basel · CHUniversity of California, Los Angeles · USUniversity of Colorado Denver · USUniversity of Florida · USUniversity of Lisbon · PTUniversity of Perugia · ITYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Italian Ministry of Health Ricerca Corrente-IRCCS MultimedicaMedtronic and the Society of Vascular and Interventional NeurologyNCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundWe identified risk factors, derived and validated a prognostic score for poor neurological outcome and death for use in cerebral venous thrombosis (CVT).

methodsWe performed an international multicenter retrospective study including consecutive patients with CVT from January 2015 to December 2020. Demographic, clinical, and radiographic characteristics were collected. Univariable and multivariable logistic regressions were conducted to determine risk factors for poor outcome, mRS 3-6. A prognostic score was derived and validated.

resultsA total of 1,025 patients were analyzed with median 375 days (interquartile range [IQR], 180 to 747) of follow-up. The median age was 44 (IQR, 32 to 58) and 62.7% were female. Multivariable analysis revealed the following factors were associated with poor outcome at 90- day follow-up: active cancer (odds ratio [OR], 11.20; 95% confidence interval [CI], 4.62 to 27.14; P<0.001), age (OR, 1.02 per year; 95% CI, 1.00 to 1.04; P=0.039), Black race (OR, 2.17; 95% CI, 1.10 to 4.27; P=0.025), encephalopathy or coma on presentation (OR, 2.71; 95% CI, 1.39 to 5.30; P=0.004), decreased hemoglobin (OR, 1.16 per g/dL; 95% CI, 1.03 to 1.31; P=0.014), higher NIHSS on presentation (OR, 1.07 per point; 95% CI, 1.02 to 1.11; P=0.002), and substance use (OR, 2.34; 95% CI, 1.16 to 4.71; P=0.017). The derived IN-REvASC score outperformed ISCVT-RS for the prediction of poor outcome at 90-day follow-up (area under the curve [AUC], 0.84 [95% CI, 0.79 to 0.87] vs. AUC, 0.71 [95% CI, 0.66 to 0.76], χ2 P<0.001) and mortality (AUC, 0.84 [95% CI, 0.78 to 0.90] vs. AUC, 0.72 [95% CI, 0.66 to 0.79], χ2 P=0.03).

conclusionsSeven factors were associated with poor neurological outcome following CVT. The INREvASC score increased prognostic accuracy compared to ISCVT-RS. Determining patients at highest risk of poor outcome in CVT could help in clinical decision making and identify patients for targeted therapy in future clinical trials.

Indexed as

PrognosisSinus thrombosis, intracranialStroke

Identifiers

PMID36221944
PMCPMC9561213
OpenAlexW4298143350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.