Evidence map›Paper›PMID 36221783›Full record

ArticleCNS neuroscience & therapeutics2023

Swimming exercise is a promising early intervention for autism-like behavior in Shank3 deletion rats.

Dan Xu, Yunchen Meng, Shasha An, Wenshu Meng, Hanran Li, Weinan Zhang, Yaqi Xue, Xinyu Lan, Xiaoxi Wang, Mingjuan Li and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Dan XuCollege of P.E and Sports, Beijing Normal University, Beijing, China.ORCID 0000-0002-6593-4109
Yunchen MengDepartment of P.E., China University of Mining and Technology-Beijing, Beijing, China.
Shasha AnCollege of P.E and Sports, Beijing Normal University, Beijing, China.
Wenshu MengCollege of Life Sciences, Beijing Normal University, Beijing, China.
Hanran LiCentre for Cognitive and Brain Sciences and Department of Psychology, University of Macau, Taipa, Macau.
Weinan ZhangCollege of P.E and Sports, Beijing Normal University, Beijing, China.
Yaqi XueCollege of P.E and Sports, Beijing Normal University, Beijing, China.
Xinyu LanDepartment of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Xiaoxi WangInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Mingjuan LiDepartment of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Xiaoyan ZhangCollege of P.E and Sports, Beijing Normal University, Beijing, China.
Zhang ZhihaoCollege of P.E and Sports, Beijing Normal University, Beijing, China.
Yu ZhaoCollege of P.E and Sports, Beijing Normal University, Beijing, China.
Haodong YangCollege of P.E and Sports, Beijing Normal University, Beijing, China.
Chen ZhangDepartment of Neurobiology, School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Rong ZhangDepartment of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China.
Zhiping ZhenCollege of P.E and Sports, Beijing Normal University, Beijing, China.
Beijing Normal University · CNPeking University · CNCapital Medical University · CNChina University of Mining and Technology · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity of Macau · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSHANK3 is an important excitatory postsynaptic scaffold protein, and its mutations lead to genetic cause of neurodevelopmental diseases including autism spectrum disorders (ASD), Philan McDermid syndrome (PMS), and intellectual disability (ID). Early prevention and treatment are important for Shank3 gene mutation disease. Swimming has been proven to have a positive effect on neurodegenerative diseases.

methodsShank3 gene exon 11-21 knockout rats were intervened by a 40 min/day, 5 day/week for 8-week protocol. After the intervention, the rats were tested to behavioral measures such as learning and memory, and the volume and H-spectrum of the brain were measured using MRI; hippocampal dendritic spines were measured using Golgi staining and laser confocal.

resultsThe results showed that Shank3-deficient rats had significant deficits in social memory, object recognition, and water maze learning decreased hippocampal volume and number of neurons, and lower levels of related scaffold proteins and receptor proteins were found in Shank3-deficient rats.

conclusionIt is suggested that early swimming exercise has a positive effect on Shank3 gene-deficient rats, which provides a new therapeutic strategy for the prevention and recovery of neurodevelopmental disorders.

Indexed as

Autism Spectrum DisorderAutistic DisorderPhysical Conditioning, AnimalAnimalsBehavior, AnimalMutationNerve Tissue ProteinsRatsSwimmingNerve Tissue ProteinsShank3 protein, ratautismearly interventionhippocampusShank3swimming exercise

Identifiers

PMID36221783
PMCPMC9804047
OpenAlexW4304620064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.