Evidence map›Paper›PMID 36221310›Full record

Observational studyInternational journal of immunopathology and pharmacology

Blood phenotype O and indirect bilirubin are associated with lower, early COVID-19-related mortality: A retrospective study.

Alaa Efat, Sabry Shoeib, Ali ElKholy, Osama Saied Hussein Aboelela, Doaa Elshamy

Abstract readObservational Study
In one paragraph

Observational study in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alaa EfatHematology Unit, Department of Internal Medicine, Faculty of Medicine, 68872Menoufia University, Shebin Al-Kom, Egypt.ORCID 0000-0001-8148-3443
Sabry ShoeibHematology Unit, Department of Internal Medicine, Faculty of Medicine, 68872Menoufia University, Shebin Al-Kom, Egypt.
Ali ElKholyHematology Unit, Department of Internal Medicine, Faculty of Medicine, 68872Menoufia University, Shebin Al-Kom, Egypt.ORCID 0000-0001-9927-7277
Osama Saied Hussein AboelelaDepartment of Intensive Care, Quena General Hospital, Qena, Egypt.
Doaa ElshamyHematology Unit, Department of Internal Medicine, Faculty of Medicine, 68872Menoufia University, Shebin Al-Kom, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the ABO blood type and indirect bilirubin to predict early mortality in adults with severe COVID-19.

methodsThis retrospective observational study was conducted on 268 adult patients with laboratory-confirmed COVID-19 who had attended the intensive care unit (ICU), Quena general hospital and Luxor International Hospital, and other hospitals or centers for the treatment of COVID-19, during the period from January 2021 till December 2021.

resultsRelation between mortality and ABO group were highly significant, as we found non-O blood group with more risk of early mortality and intensive care unit admission ICU. There were significant differences between dead and alive cases as regards platelets, white blood cells WBCs (neutrophil, lymphocyte), albumin, liver enzymes aspartate transeferase (AST), alanine transferase (ALT), total direct and indirect bilirubin, creatinine, and urea.

conclusionThere was a highly significant relation between dead cases and ABO blood group as between the O and non-O groups; also, group O was associated with less severe manifestations and or ventilation and less mortality in patients with severe COVID-19 infection. Direct bilirubin >0.5 was found to be the best predictor for mortality in cases with COVID-19 so indirect bilirubin may be considered a good protector against complications of the infection.

Indexed as

COVID-19ABO Blood-Group SystemAlanineAlanine TransaminaseAlbuminsAspartic AcidBilirubinCreatinineHumansPhenotypeRetrospective StudiesSARS-CoV-2UreaABO Blood-Group SystemAlanineAlanine TransaminaseAlbuminsAspartic AcidBilirubinCreatinineUreaABO blood typebilirubinCOVID-19mortalityseverity

Identifiers

PMID36221310
PMCPMC9554569

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.