Evidence map›Paper›PMID 36221269›Full record

ArticleOpen forum infectious diseases2022

Prediction of Symptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Quantitative Digital Polymerase Chain Reaction Normalized to International Units.

Diego R Hijano, Zhengming Gu, Jessica Brazelton, Haiqing Zhu, Sri Suganda, Heather L Glasgow, Himani Darji, Li Tang, Thomas P Fabrizio, Kim J Allison and 7 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Digital PCR to Measure SARS-CoV-2 RNA, Variants, and Outcomes in Youth.Journal of the Pediatric Infectious Diseases Society · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Diego R HijanoDepartments of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-2903-666X
Zhengming GuDepartments of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jessica BrazeltonDepartments of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Haiqing ZhuDepartments of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Sri SugandaDepartments of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Heather L GlasgowDepartments of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-6594-9837
Himani DarjiDepartments of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Li TangDepartments of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Thomas P FabrizioDepartments of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kim J AllisonDepartments of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
E Kaitlynn AllenDepartments of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
SJTRC Study Team
Aditya H GaurDepartments of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Joshua WolfDepartments of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-9912-3646
Paul G ThomasDepartments of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Richard J WebbyDepartments of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Randall T HaydenDepartments of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
St. Jude Children's Research Hospital · US

Funding

COVID Supplement - COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES,75N93019C00052 · NIAID · UNIVERSITY OF GEORGIA · PI ROSS, TED · 2019 to 2025
$74.6M
Household Respiratory Virus SARS-CoV-2 Transmission and Immunity Sub-Study (HRTS)U01AI144616 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GORDON, AUBREE L, THOMAS, PAUL G. · 2019 to 2025
$43.7M
NIAID NIH HHS U01 AI144616NIH HHS 75N93019C00052
6 · The paper itself

Abstract

Although numerous studies have evaluated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using cycle threshold (Ct) values as a surrogate of viral ribonucleic acid (RNA) load, few studies have used standardized, quantitative methods. We validated a quantitative SARS-CoV-2 digital polymerase chain reaction assay normalized to World Health Organization International Units and correlated viral RNA load with symptoms and disease severity.

Indexed as

COVID-19digital PCRinternational unitsSARS-CoV-2viral load

Identifiers

PMID36221269
PMCPMC9494499
OpenAlexW4296704976

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.