Evidence map›Paper›PMID 36221235›Full record

SynthesisInternational journal of geriatric psychiatry2022

Cognitive impairment in people with physical frailty using the phenotype model: A systematic review and meta analysis.

Ali Vahedi, Maria Eriksdotter, Hege Ihle-Hansen, Torgeir Bruun Wyller, Anne Rita Øksengård, Brynjar Fure

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of geriatric psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Association Between Frailty and Cognitive Impairment in Chronic Kidney Disease: A Systematic Review and Meta-Analysis.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026
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  16. Association between pre-stroke frailty status and post-stroke cognitive impairment in patients with acute large artery atherosclerotic cerebral infarction.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Ali VahediDepartment of Internal Medicine, Section of Geriatric Medicine, Central Hospital Karlstad, Karlstad, Sweden.ORCID 0000-0002-7642-4630
Maria EriksdotterDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Hege Ihle-HansenStroke Unit, Department of Neurology, Oslo University Hospital, Oslo, Norway.
Torgeir Bruun WyllerInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Anne Rita ØksengårdHead of Science, Nasjonalforeningen for Folkehelsen, Oslo, Norway.
Brynjar FureDepartment of Internal Medicine, Section of Geriatric Medicine, Central Hospital Karlstad, Karlstad, Sweden.
Örebro University · SEOslo University Hospital · NOKarolinska University Hospital · SENasjonalforeningen for Folkehelsen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe performed a systematic review and meta-analysis to study the relationship between cognitive functioning and phenotypic frailty status.

methodsWe searched Pubmed, Cochrane Library and Epistemonikos from 2000 until March 2022, and used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Samples included both sexes, age ≥55 years, assessed with standardized measures of the different cognitive domains and the frailty phenotype model and analyzing the relationship between the frailty subtypes pre-frail, frail and robust and specific cognitive function.

resultsEleven studies published from 2008 until March 2022 fulfilled the inclusion criteria, and 10 were included in our meta-analyses. Sample sizes varied from 104 to 4649 individuals. Mean Mini-Mental State Examination (MMSE) scores ranged from 17.0 to 27.6, with mean difference (MD) of -2.55 (95% confidence interval [CI] -3.32, -1.78) in frail compared to robust, MD -1.64 (95% CI -2.21, -1.06) in frail compared to prefrail and MD -0.68 (95% CI -0.94, -0.43) in prefrail compared to robust. In subgroup analyses, frail persons had lower scores in the memory domain with standardized mean difference (SMD) -1.01 (95% CI -1.42, -0.59).

conclusionMMSE scores were significantly lower in frail compared to robust and prefrail persons and in prefrail compared to robust persons. Subgroup analysis of memory revealed significantly poorer scores in frail compared to robust. The results indicate a strong relationship between physical frailty and cognitive impairment suggesting incorporation of cognitive function in frailty assessments.

Indexed as

Cognitive DysfunctionFrailtyAgedCognitionFemaleFrail ElderlyGeriatric AssessmentHumansMalePhenotypeaging, cognitive domainscognitive impairmentselderlymeta-analysisolder personsphysical frailtysystematic review

Identifiers

PMID36221235
PMCPMC9828066
OpenAlexW4301595292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.