Evidence map›Paper›PMID 36221190›Full record

SynthesisBJS open2022

Routine pathologic evaluation of circular stapler anastomotic rings is not useful after resection for colorectal cancer: retrospective study and systematic review with meta-analysis.

James R Holden, Pam McIntosh, Garrett G R J Johnson, Jason Park, David J Hochman, Ashley Vergis, Benson Yip, Ramzi M Helewa, Eric Hyun

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BJS open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

James R HoldenDepartment of Surgery, University of Manitoba and St. Boniface Hospital, Winnipeg, Manitoba, Canada.ORCID 0000-0003-1746-2079
Pam McIntoshDepartment of Surgery, University of Manitoba and St. Boniface Hospital, Winnipeg, Manitoba, Canada.
Garrett G R J JohnsonDepartment of Surgery, University of Manitoba and St. Boniface Hospital, Winnipeg, Manitoba, Canada.
Jason ParkDepartment of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.
David J HochmanDepartment of Surgery, University of Manitoba and St. Boniface Hospital, Winnipeg, Manitoba, Canada.
Ashley VergisDepartment of Surgery, University of Manitoba and St. Boniface Hospital, Winnipeg, Manitoba, Canada.
Benson YipDepartment of Surgery, University of Manitoba and St. Boniface Hospital, Winnipeg, Manitoba, Canada.
Ramzi M HelewaDepartment of Surgery, University of Manitoba and St. Boniface Hospital, Winnipeg, Manitoba, Canada.
Eric HyunDepartment of Surgery, University of Manitoba and St. Boniface Hospital, Winnipeg, Manitoba, Canada.
St. Boniface Hospital · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCircular staplers are commonly used for reconstruction after radical resection for colorectal cancer. Pathological analysis of the anastomotic rings is common practice, although the benefits are unclear. The purpose of this study was to evaluate the usefulness of routine histopathological analysis of anastomotic rings in an original series and in a systematic review of the literature.

methodThe retrospective study was performed at two university-associated academic hospitals in Winnipeg, Canada, including patients investigated for colorectal cancers (within 30 cm of the anal verge) who underwent resection between 2007 and 2020. The systematic review involved Ovid MEDLINE, Embase, Scopus, and Web of Science databases, selecting for adult human studies involving analysis of anastomotic rings in elective colorectal cancer resections. The main outcome measure was the proportion of patients with cancer in the anastomotic ring specimens. The frequency of benign pathology findings and changes to patient management were also examined.

resultsOut of 673 eligible patients, 487 were included in the retrospective analysis. No patients had cancer within the anastomotic ring specimens. Twenty-five patients (5.1 per cent) had benign pathological findings within the anastomotic ring specimens, and patient management was never affected. In the systematic review, 27 articles were included in the final analysis out of 5848 records reviewed. The rate of cancer within anastomotic ring specimens was 0.34 per cent, and the rate of change in patient management was 0.19 per cent.

conclusionThe likelihood of finding cancer within anastomotic rings is rare and their histopathological examination seldom changes patient management.

Indexed as

Colorectal NeoplasmsSurgical StaplingAdultAnal CanalAnastomosis, SurgicalHumansRetrospective Studies

Identifiers

PMID36221190
PMCPMC9553864
OpenAlexW4304589920

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.