Evidence map›Paper›PMID 36220605›Full record

ReviewJournal of child psychology and psychiatry, and allied disciplines2023

Annual Research Review: Perspectives on progress in ADHD science - from characterization to cause.

Edmund J S Sonuga-Barke, Stephen P Becker, Sven Bölte, Francisco Xavier Castellanos, Barbara Franke, Jeffrey H Newcorn, Joel T Nigg, Luis Augusto Rohde, Emily Simonoff

Abstract readReview
In one paragraph

Review in Journal of child psychology and psychiatry, and allied disciplines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Review
  2. Article
  3. Executive function challenges persist into young adulthood and predict mental health outcomes in autism.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The Role of GDNF and NSE in Attention-deficit/Hyperactivity Disorder: The Relationship with Sleep and Eating.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Edmund J S Sonuga-BarkeSchool of Academic Psychiatry, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, UK.ORCID 0000-0002-6996-3935
Stephen P BeckerDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-1932-8159
Sven BölteDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Francisco Xavier CastellanosDepartment of Child and Adolescent Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.
Barbara FrankeDepartments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-4375-6572
Jeffrey H NewcornIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Joel T NiggDepartment of Psychiatry, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0003-0003-3024
Luis Augusto RohdeADHD Outpatient Program and Developmental Psychiatry Program, Hospital de Clinica de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Emily SimonoffSchool of Academic Psychiatry, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, UK.

Funding

ADHD heterogeneity, mechanisms, and risk profileR37MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 2014 to 2023
$7.0M
2/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124851 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOERGLUM, ANDERS, DAVIS, LEA K · 2021 to 2025
$5.4M
Longitudinal Examination of Sluggish Cognitive Tempo and Internalizing Psychopathology in AdolescenceR01MH122415 · NIMH · CINCINNATI CHILDRENS HOSP MED CTR · PI BECKER, STEPHEN P · 2021 to 2025
$3.8M
Brain trajectories in ADHDR01MH115357 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI FAIR, DAMIEN A, NIGG, JOEL T · 2017 to 2021
$3.8M
NEUROPSYCHOLOGICAL AND FAMILIAL MARKERS FOR CHILD ADHDR01MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 1999 to 2012
$3.3M
ADHD biotypes using genetic and imaging approachesR01MH099064 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 2013 to 2017
$3.2M
Imaging Stimulant and NonStimulant Treatments for ADHD: A Network-Based ApproachR01MH095766 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI NEWCORN, JEFFREY H, SCHULZ, KURT P. · 2012 to 2016
$3.2M
Predicting Response to Atomoxetine and MethlyphenidateR01MH070935 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI NEWCORN, JEFFREY H · 2005 to 2009
$3.0M
Brain plasticity underlying acquisition of new organizational skills in childrenR33MH113663 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CASTELLANOS, FRANCISCO XAVIER · 2019 to 2021
$2.6M
Inhibition and Cognition in Adolescent and Adult ADHDR01MH063146 · NIMH · MICHIGAN STATE UNIVERSITY · PI NIGG, JOEL T · 2001 to 2004
$1.6M
Medical Research Council MR/W002493/1NIMH NIH HHS R01 MH059105NIMH NIH HHS R01 MH063146NIMH NIH HHS R01 MH070935NIMH NIH HHS R01 MH095766NIMH NIH HHS R01 MH099064NIMH NIH HHS R01 MH115357NIMH NIH HHS R01 MH122415NIMH NIH HHS R01 MH124851NIMH NIH HHS R33 MH113663NIMH NIH HHS R37 MH059105
6 · The paper itself

Abstract

The science of attention-deficit/hyperactivity disorder (ADHD) is motivated by a translational goal - the discovery and exploitation of knowledge about the nature of ADHD to the benefit of those individuals whose lives it affects. Over the past fifty years, scientific research has made enormous strides in characterizing the ADHD condition and in understanding its correlates and causes. However, the translation of these scientific insights into clinical benefits has been limited. In this review, we provide a selective and focused survey of the scientific field of ADHD, providing our personal perspectives on what constitutes the scientific consensus, important new leads to be highlighted, and the key outstanding questions to be addressed going forward. We cover two broad domains - clinical characterization and, risk factors, causal processes and neuro-biological pathways. Part one focuses on the developmental course of ADHD, co-occurring characteristics and conditions, and the functional impact of living with ADHD - including impairment, quality of life, and stigma. In part two, we explore genetic and environmental influences and putative mediating brain processes. In the final section, we reflect on the future of the ADHD construct in the light of cross-cutting scientific themes and recent conceptual reformulations that cast ADHD traits as part of a broader spectrum of neurodivergence.

Indexed as

Attention Deficit Disorder with HyperactivityBrainHumansPhenotypeQuality of LifeSocial StigmaADHDbrain imagingdevelopmentgeneticsstigma

Identifiers

PMID36220605
PMCPMC10023337

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.