Evidence map›Paper›PMID 36220355›Full record

ArticleAmerican heart journal2023

Reducing ethnic and racial disparities by improving undertreatment, control, and engagement in blood pressure management with health information technology (REDUCE-BP) hybrid effectiveness-implementation pragmatic trial: Rationale and design.

Julie C Lauffenburger, Rasha Khatib, Alvia Siddiqi, Michelle A Albert, Punam A Keller, Lipika Samal, Nicole Glowacki, Marlon E Everett, Kaitlin Hanken, Simin G Lee and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in American heart journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05030467 (Leveraging Electronic Health Record), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05030467 nacompletednot on this map

Leveraging Electronic Health Record (EHR) Tools to Reduce Health Disparities for Patients With Uncontrolled Hypertension

TypeinterventionalSponsorBrigham and Women's HospitalRan2022 to 2024Enrolled49,210ConditionsHypertension, Blood PressureArmsREDUCE-BP Intervention
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Decreased racial disparities in sepsis mortality after an order set-driven initiative: An analysis of 8151 patients.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Julie C LauffenburgerCenter for Healthcare Delivery Sciences (C4HDS), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. Electronic address: jlauffenburger@bwh.harvard.edu.
Rasha KhatibAdvocate Aurora Research Institute, Advocate Aurora Health, Downers Grove, IL.
Alvia SiddiqiEnterprise Population Health, Advocate Aurora Health, Downers Grove, IL.
Michelle A AlbertCenter for the Study of Adversity and Cardiovascular Disease (NURTURE Center), Division of Cardiology of Medicine (Cardiology), University of California, San Francisco, San Francisco, CA.
Punam A KellerTuck School of Business, Dartmouth College, Hanover, NH.
Lipika SamalDivision of General Internal Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Nicole GlowackiAdvocate Aurora Research Institute, Advocate Aurora Health, Downers Grove, IL.
Marlon E EverettAdvocate Heart Institute, Advocate Aurora Health, Chicago, IL.
Kaitlin HankenCenter for Healthcare Delivery Sciences (C4HDS), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Simin G LeeCenter for Healthcare Delivery Sciences (C4HDS), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Gauri BhatkhandeCenter for Healthcare Delivery Sciences (C4HDS), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Nancy HaffCenter for Healthcare Delivery Sciences (C4HDS), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Ellen S SearsCenter for Healthcare Delivery Sciences (C4HDS), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Niteesh K ChoudhryCenter for Healthcare Delivery Sciences (C4HDS), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Funding

Leveraging electronic health record tools to reduce health disparities for patients with uncontrolled hypertensionR01MD014874 · NIMHD · BRIGHAM AND WOMEN'S HOSPITAL · PI CHOUDHRY, NITEESH K, LAUFFENBURGER, JULIE CHRISTINE · 2020 to 2024
$3.4M
Development of an implementation-ready antihypertensive self-titration intervention to improve US blood pressure controlK23HL161480 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Nancy Haff · 2022 to 2026
$826k
NHLBI NIH HHS K23 HL161480NIMHD NIH HHS R01 MD014874
6 · The paper itself

Abstract

backgroundWhile racial/ethnic disparities in blood pressure control are documented, few interventions have successfully reduced these gaps. Under-prescribing, lack of treatment intensification, and suboptimal follow-up care are thought to be central contributors. Electronic health record (EHR) tools may help address these barriers and may be enhanced with behavioral science techniques.

objectiveTo evaluate the impact of a multicomponent behaviorally-informed EHR-based intervention on blood pressure control. TRIAL

designReducing Ethnic and racial Disparities by improving Undertreatment, Control, and Engagement in Blood Pressure management with health information technology (REDUCE-BP) (NCT05030467) is a two-arm cluster-randomized hybrid type 1 pragmatic trial in a large multi-ethnic health care system. Twenty-four clinics (>350 primary care providers [PCPs] and >10,000 eligible patients) are assigned to either multi-component EHR-based intervention or usual care. Intervention clinic PCPs will receive several EHR tools designed to reduce disparities delivered at different points, including a: (1) dashboard of all patients visible upon logging on to the EHR displaying blood pressure control by race/ethnicity compared to their PCP peers and (2) set of tools in an individual patient's chart containing decision support to encourage treatment intensification, ordering home blood pressure measurement, interventions to address health-related social needs, default text for note documentation, and enhanced patient education materials. The primary outcome is patient-level change in systolic blood pressure over 12 months between arms; secondary outcomes include changes in disparities and other clinical outcomes.

conclusionREDUCE-BP will provide important insights into whether an EHR-based intervention designed using behavioral science can improve hypertension control and reduce disparities.

Indexed as

HypertensionMedical InformaticsBlood PressureBlood Pressure DeterminationDelivery of Health CareHumansPragmatic Clinical Trials as TopicRandomized Controlled Trials as Topic

Identifiers

PMID36220355
PMCPMC9742137

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.